Recording of Myometrial Activity in the Non‐Pregnant Human Uterus by a Micro‐Transducer Catheter

Åkerlund, Mats; Bengtsson, Lars Ph.; Ulmsten, Ulf

doi:10.3109/00016347809156524

Cited by 42 publications

(22 citation statements)

References 7 publications

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“…Endometrial wave‐like movements are associated with myometrial contraction 4 . Myometrial contraction can be assessed by uterine cavity pressure 16–18 . Thus, it is of interest to determine whether changes in endometrial wave‐like movements synchronize with changes in uterine cavity pressure.…”

Section: Discussionmentioning

confidence: 99%

Changes in endometrial wave‐like movements in accordance with the phases of menstrual cycle

Oki

Douchi

Maruta

et al. 2002

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Changes in endometrial wave‐like movements in accordance with the phases of menstrual cycle

Oki

Douchi

Maruta

et al. 2002

J of Obstet and Gynaecol

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“…This procedure, however, en counters medical and ethical contra-indications when used just for research purposes. Micro-transducers at the catheter tip were not used because of possible ar tifacts [15] and the impossibility of calibration during the recording [16].…”

Section: Discussionmentioning

confidence: 99%

Oral administration of methylergometrine shows a late and unpredictable effect on the non-pregnant human menstruating uterus

Groot¹,

Dongen²,

Vree³

et al. 1995

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective: To study the pharmacodynamic and pharmacokinetic properties of oral and intravenous methylergometrine upon uterine motility during menstruation. Study-design: Intra-uterine pressure was measured in six volunteers with a fluid-filled spongetipped catheter during menstruation. Methylergometrine was given orally (0.5 mg) or intravenously (0.2 mg) in a cross-over design. Results: After intravenous administration, a fast increase of the frequency of uterine contractions and basal tone occurred with a decrease of amplitude, lasting at least 30 min. Oral administration had a late and less marked effect on uterine motility. An intra venous dose administered 24 h after an oral dose had no effect on uterine motility. Pharmacokinetic data, such as the maximum plasma concentration (Cmax), the time at which Cmax is reached (tmax) and the half-life of absorption a^so demonstrated large individual variations after oral administration. Conclusion: Oral administration of methylergometrine had an unpredictable and late effect on uterine motility on the menstruating uterus, probably due to an unpredictable bioavailability, in contrast with the fast and predictable effect after intravenous administration.

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“…For intrauterine pressure recordings, a microtransducer catheter (Model PC 470;Millar Instruments,Houston,Texas,U.S.A. ) (Akerlund, Bengtsson & Ulmsten, 1976) was inserted through a small incision at the ovarian end of the right uterine horn and the sensor of the catheter was placed in the middle part of that horn. The pressure transducer was connected to an amplifier (EMT-311 : Elema-Siemens, Stockholm, Sweden) and a potentiometer recorder (Omniscribe; Houston Instruments, Texas, U.S.A.).…”

Section: Methodsmentioning

confidence: 99%

Differences in the effects of vasopressin and oxytocin on rabbit myometrial activity and a possible mediation of prostaglandins

Laudański¹,

Åkerlund²,

Batra³

1977

Reproduction

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Uterine responses to vasopressin and oxytocin were monitored in non-pregnant and 3- or 6-8-day-pregnant rabbits by recording the intrauterine pressure. Oxytocin stimulated uterine activity in all groups, but the effect of vasopressin was stimulatory in non-pregnant animals, inhibitory in those 3 days post coitum and weakly stimulatory in those later in pregnancy. Inhibition of prostaglandin (PG) synthesis, by the administration of indomethacin, reduced the spontaneous uterine activity as well as the responses to oxytocin and vasopressin in the non-pregnant rabbits, but had little effect in the pregnant animals. During infusion of PGF-2alpha, PGE-1 or PGE-2 in 6-8-day-pregnant rabbits, the stimulatory response to vasopressin, although slight before the infusion, was inhibited whereas the stimulatory response to oxytocin remained virtually unchanged. The results suggest that vasopressin and oxytocin under certain hormonal conditions, are able to activated the uterine contractions by mechanisms in which the involvement of PG is not obligatory.

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Recording of Myometrial Activity in the Non‐Pregnant Human Uterus by a Micro‐Transducer Catheter

Cited by 42 publications

References 7 publications

Changes in endometrial wave‐like movements in accordance with the phases of menstrual cycle

Changes in endometrial wave‐like movements in accordance with the phases of menstrual cycle

Oral administration of methylergometrine shows a late and unpredictable effect on the non-pregnant human menstruating uterus

Differences in the effects of vasopressin and oxytocin on rabbit myometrial activity and a possible mediation of prostaglandins

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