Record Ultralarge‐Pores, Low Density Three‐Dimensional Covalent Organic Framework for Controlled Drug Delivery**

Abstract

The unique structural characteristics of threedimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non-interpenetrated stp net COF, namely TUS-64, with the largest pore size of all 3D COFs (47 Å) and record-low density (0.106 g cm À 3 ) by reticulating a 6-connected triptycenebased linker with a 4-connected porphyrin-based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS-64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS-64 as drug nanocarriers.

Construction of dense H-bond acceptors in the channels of covalent organic frameworks for proton conduction

“…COFs have high thermal stability, structural tunability, large specic surface area and a well-dened pore structure. [19][20][21][22][23][24] These unique features have led COFs to be widely used in gas adsorption/separation, 25,26 catalysis, [27][28][29][30] electronic devices, 31,32 drug delivery 33,34 and chemical sensors. 35,36 Importantly, the open and straight pore channels of two-dimensional COFs provide a fast pathway for ionic conduction.…”

Reticular chemistry within three-dimensional covalent organic frameworks for multiple applications

“…Subsequently, they reported TUS-64 with a record ultralarge pore of 47 Å and ultra-low density of 0.106 g cm −3 , exhibiting effective drug loading and controlled release of ve different drugs in a simulated body uid environment. 113 Remarkably, TUS-64 showed a high loading of 17.34 wt% for anticancer drug 5-uorouracil and a sustained release rate of about 12% aer 9 days.…”

Post-synthetic modifications of covalent organic frameworks (COFs) for diverse applications

“…Due to the topology and linkage diversity as well as building monomers with different sizes, reactive groups, chiral centers, and docking sites, various COFs have been constructed. 2 Due to their specific attributes, these compounds have found usage in catalysis, 3,4 sensors, [5][6][7] separation, 8,9 adsorption, [10][11][12][13] energy storage, [14][15][16] drug delivery, [17][18][19][20] and electronic devices. [21][22][23] Functional groups of COFs play a key role in these applications.…”