Reconstructive problems in canine liver homotrans-plantation with special reference to the postoperative role of hepatic venous flow

Abstract

FIG. 1. Basic technique of homotransplantation. a, Ilonor liver readv for transplant. Note aortic graft removed in continuity with hepatic artery and livcr graft. b, Rccipicnt with portacaval shunt and liver removed. c, Donor liver in place.

Histopathologic alterations associated with the transplanted homologous dog liver

“…The technical problems and clinical course after transplantation of the homologous dog liver have been recently described (Moore et al, 1960;Starzl et al, 1960Starzl et al, , 1961. The rejection pattern was similar to that seen with other vascularized homografts.…”

“…The technique of liver transplantation was previously described (Starzl et al, 1960). The graft was placed within the liver fossa after removal of the recipient dog's liver.…”

“…Residual evidence of outflow block was sometimes present in long-term survivors. Such changes are known to be due to hepatic ischemia rather than a specific effect of homotransplantation (Starzl et al, 1960).…”

The Role of Organ Transplantation in Pediatrics

“…The most incisive experiments have involved orthotopic transplantation in which the recipient animal's own liver is excised and replaced with a homograft obtained from an unrelated mongrel animal 31,35,36,37,50,51,58 with a technique similar to that depicted in Figure 38. With this preparation there is no equivocation about the presence or absence of transplant viability, since survival provides incontrovertible proof of continuous homograft function.…”

The anterior route for arterial graft conduits in liver transplantation

“…The so-called conduit techniques for arterialization of orthotoptic liver homografts were first developed in the laboratory [2] and later applied in the clinic [1,3,4]. With most of these procedures, the arterial grafts have been tunneled posterior to the duodenum, passing either to the right or to the left of the superior mesenteric artery, in a plane just anterior to the inferior vena cava and left renal vein [4].…”