Reconstruction of trochanteric pressure sores with pedicled anterolateral thigh myocutaneous flaps

Wang, Chih-Hsin; Chen, Shih-Yi; Fu, Ju-Peng; Dai, Niann‐Tzyy; Chen, Shao‐Liang; Chen, Tim‐Mo; Chen, Shyi-Gen

doi:10.1016/j.bjps.2010.08.042

Cited by 26 publications

(33 citation statements)

References 16 publications

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“…Consequently, as “living tissue replacements”, tissue grafts (autogenous or allogenic tissue grafts) and donor organs of human origin can be considered as the gold standard “biomaterials” for reconstructive therapies [115,116] (Fig. 4).…”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

“…An overview of the advantages and disadvantages of each tissue resource (external or internal) and types of grafts will provide surgeons validated principles regarding graft choice during clinical practice. Furthermore, understanding the native tissue composition and structure and revisiting the observed clinical benefits related to tissue grafts can offer practicing tissue engineers important information on state-of-the-art biomaterial evolution and design inspiration [115,136]. …”

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

See 1 more Smart Citation

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

926

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

Section: Tissue Grafts Of Human Originmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

926

513

View full text Add to dashboard Cite

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“…The V-Y modification of the tensor fascia lata provides a better vascularized proximal tissue, as well as providing more muscle bulk to fill the dead space in a pressure sore. Wang et al 6 reported the use of pedicled anterolateral thigh myocutaneous flaps for trochanteric pressure sore reconstruction with good results. Classically, the anterior border of the tensor fascia lata flap is a line connecting the anterior-superior iliac crest and the lateral condyle of the knee.…”

Section: Discussionmentioning

confidence: 98%

Expanding the Applications of the Pedicled Anterolateral Thigh and Vastus Lateralis Myocutaneous Flaps

Hsu¹,

Chien²,

Wang³

et al. 2012

Annals of Plastic Surgery

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We describe our experience in expanding the use of pedicled anterolateral thigh and vastus lateralis myocutaneous flaps. A total of 33 patients underwent 34 flaps between March 2003 and January 2012. The defects included 18 ischial, 3 trochanteric, 5 lower abdomen, 2 perineogenital, 1 groin, and 5 knee defects. There were 29 proximal pedicled (2 of which were preexpanded), 3 distal pedicled, and 2 propeller flaps. Complications included 1 total necrosis, 1 partial necrosis, 3 wound dehiscence in recipient site, 1 hematoma, and 1 donor-site dehiscence. The total flap survival rate was 94%. There were no donor-site morbidities except poor cosmesis in the skin-grafted sites. Pedicled anterolateral thigh flap is highly versatile with a wide arc of rotation. A proximal pedicled flap can be used for lower abdomen, perineogenital, ischial, and trochanteric defects and the distal pedicled or a propeller flap for knee and proximal lower leg defects.

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“…Wang et al described pedicled ALT flap, which provided a reliable cover to the trochanteric region in the management of recurrent trochanteric pressure sores [10]. When the ALT flap was tunnelled through the muscular compartments of thigh, it could be utilised to resurface the ischial pressure ulcers [11].…”

Section: Discussionmentioning

confidence: 99%