Reconstruction of the Rabbit Trachea with Vascularized Auricular Perichondrium

Naficy, Saman; Esclamado, Ramon M.; Clevens, Ross A.

doi:10.1177/000348949610500505

Cited by 18 publications

(22 citation statements)

References 13 publications

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“…8 In paediatric age group incidence of post intubation tracheal stenosis is higher (66.6%) than adults which is comparable to study of laryngeotracheal stenosis in pediatric age group by Rami T Younis et al where incidence is 80%, this shows that pediatric age group is more vulnerable to post intubation tracheal stenosis.…”

Section: Discussionsupporting

confidence: 80%

Evaluation of management of tracheal stenosis: our experience of 25 patients

Swami

Bharath

Chaitra

2016

Int J Otorhinolaryngol Head Neck Surg

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Background: This study was conducted at a tertiary referral centre. Tracheal stenosis is a relatively rare complication, the chief etiologies being prolonged intubation and trauma. The management is difficult and requires variety of skill based procedures which can be either endoscopic or open technique. Our objective was to determine factors for deciding on the type of surgery required for patients with tracheal stenosis.Methods: 25 consecutive patients of tracheal stenosis referred to our department were selected after confirming the diagnosis by fibre optic examination and CT scan. Results: All the patients were managed using various techniques. Long segment and circumfrential stenosis underwent resection and anastamosis. Other cases were managed by either endoscopic techniques or tracheoplasty.Conclusions: The main factors for deciding the type of intervention are the length of stenotic segment and presence circumferential stenosis.

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Section: Discussionsupporting

confidence: 80%

Evaluation of management of tracheal stenosis: our experience of 25 patients

Swami

Bharath

Chaitra

2016

Int J Otorhinolaryngol Head Neck Surg

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“…The perichondrium is a membrane of dense connective tissue that surrounds airway cartilage, and that has chondrogenic potential. Various animal studies have shown that the perichondrium can form new cartilage, 5–8 but the amounts were variable and rather small in these animal studies. It is not clear how the perichondrium develops, nor is it clear how perichondrium productivity depends on various factors 22,23 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, MPCs are present in the perichondrium 5 . The perichondrium has been used in experimental models of laryngotracheal reconstruction, and there is clear evidence that it has chondrogenic potential 6–8 …”

mentioning

confidence: 99%

Cell origin in experimental repair of cricoid cartilage defects treated with recombinant human bone morphogenetic protein‐2

Tcacencu

Carlsöö

Stierna

2005

Wound Repair Regeneration

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We determined the origin of new cartilage and new bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2) at the site of cricoid cartilage defects in rabbits randomly divided into eight groups. The cricoid cartilage was split vertically along the anterior midline and a strip was excised from the anterior part of the cricoid cartilage in all rabbits. The perichondrium from the anterior part of the cricoid cartilage was trimmed off in four groups; two groups treated with rhBMP-2 and two control groups. In four other groups, the anterior perichondrium was detached and used as a flap with two groups treated with rhBMP-2 and two groups serving as controls. The rabbits were killed 1 week or 4 weeks after surgery. The larynges were removed, fixed and sectioned, and the sections were stained for light microscopy using various cytochemical and immunological techniques. New cartilage was only present close to the host perichondrium adherent to cricoid cartilage in rabbits treated with rhBMP-2. New bone was present 4 weeks after surgery, although calcified matrix and alkaline phosphatase activity could be detected at the site of cricoid defects as early as 1 week after surgery. The cell proliferation marker Ki-67 was strongly expressed in granulation tissue and bone marrow, and it was moderately expressed in muscles adjacent to the cricoid cartilage in rhBMP-2-treated specimens. BMP receptors were strongly expressed in cartilage and moderately expressed in adjacent muscles. We conclude that new cartilage originates from the mesenchymal progenitor cells of host perichondrium adherent to cricoid cartilage in rabbits treated with rhBMP-2. New bone may originate from local muscle.

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“…Foggia et al quantified this in their study, describing a mean cricoid cross‐sectional area of 15.7 mm 2 in adult rabbits . In addition, the availability of a large quantity of harvestable cartilage for graft material (auricular cartilage), as well as the ability to harvest costal cartilage, is of importance during reconstruction . Two studies also comment on the similarity of the laryngotracheal anatomy between rabbits and humans .…”

Section: Resultsmentioning

confidence: 99%

“…28 In addition, the availability of a large quantity of harvestable cartilage for graft material (auricular cartilage), as well as the ability to harvest costal cartilage, is of importance during reconstruction. 19,24,[29][30][31][32][33][34] Two studies also comment on the similarity of the laryngotracheal anatomy between rabbits and humans. 20,24 As all the studies utilized rabbits for in vivo experiments, several articles also highlight positive aspects of the rabbit model that only apply to the use of live rabbits.…”

Section: Rabbit Modelmentioning

confidence: 99%

A systematic review of simulated laryngotracheal reconstruction animal models

et al. 2018

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Objectives Review of the literature to identify practical, high‐fidelity, commercially available animal models for simulation training and surgical skills maintenance in laryngotracheal reconstruction (LTR). Methods A systematic review of PubMed and Embase databases was conducted independently by two authors, according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Search terms included “laryngotracheal reconstruction,” “laryngotracheoplasty,” “pig and larynx,” “sheep and larynx,” and “rabbit and larynx.” Articles were then assessed, identifying model cost and availability, model validation, feasibility as a training tool, and verisimilitude to pediatric LTR. Results In total, 79 articles were considered suitable for inclusion in the study, incorporating both in vitro and in vivo models. Models utilized included rabbit (n = 69), pig (n = 7), sheep (n = 1), and goat (n = 2). The rabbit model was similar in size to the neonate, but differences in laryngeal anatomy and cartilage texture made graft insertion difficult. The anatomy of the pig, sheep, and goat larynges more closely resembled the pediatric patient, allowing improved grafting, but corresponded more in size to that of an older child. Commercial availability of the pig and sheep was considered greatest, and was reflected in cost. None of the animal models identified in the literature have been validated as a simulation tool. Conclusions The rabbit, sheep and pig models seemed to demonstrate the greatest potential for use as advanced pediatric airway surgery simulation models, with the rabbit model being most utilized in the literature. However, as yet there have been no models formally validated as a simulation training tool. Laryngoscope, 129:235–243, 2019

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Reconstruction of the Rabbit Trachea with Vascularized Auricular Perichondrium

Cited by 18 publications

References 13 publications

Evaluation of management of tracheal stenosis: our experience of 25 patients

Evaluation of management of tracheal stenosis: our experience of 25 patients

Cell origin in experimental repair of cricoid cartilage defects treated with recombinant human bone morphogenetic protein‐2

A systematic review of simulated laryngotracheal reconstruction animal models

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