Reconstruction of the primate mandible with a combination graft of recombinant human bone morphogenetic protein-2 and bone marrow

Bone regeneration in mandible defect with autograft bone and cell suspension from bone marrow in rabbits

“…Such data suggests that, as the defect was filled in with graft regarded as perfect, presenting viable cells, this difference might have not been so considerable. In addition, differences in animals that received mesenchymal stem cells were statically significant only when little or no bone defect reparation was observed in the control groups (Seto et al, 2001;Shang et al, 2001;He et al, 2007). This fact did not occur in the control group in this study.…”

Mandibular bone repair by implantation of rhBMP-2 in a slow release carrier of polylactic acid—An experimental study in rats

“…Collagen, collagen/HA/TCP, anorganic bovine bone, hyaluronic acid, PLA/PGA coated gelatine sponges and PGLA beads have been employed with various doses of either rhBMP-2, rhBMP4 or rhBMP7 [33][34][35][36][37][38][39] All carriers of these studies had been soak-loaded with their respective BMP solution, in one study rhBMP-2 was suspended in PGLA/dioxane solution and freeze-dried for implantation [40].…”

Tissue-Engineered Mandibular Bone Reconstruction for Continuity Defects: A Systematic Approach to the Literature

“…108 Research was done in rabbits, 30 , and monkeys. 15,18,29,99,[101][102][103]109 In several studies, teeth were extracted in advance, and oral mucosa was allowed to heal completely before resective surgery and reconstructive therapy. 4,26,105,106 Beside the diversity in animal models, study design as well as healing periods after reconstructive surgery (range: 4-48 weeks) were not uniform.…”

“…Furthermore, in total, 15 scientific papers 15,18,29,31,32,[97][98][99][101][102][103]105,106,109,110 reporting on recombinant human bone morphogenetic protein-2 (rhBMP-2) as well as five publications 16,17,19,30,33 presenting data on recombinant human bone morphogenetic protein-7 (rhBMP-7) were eventually included in the current systematic approach. Thereby, the brief summarized studies of Kontaxis et al, 16 Abu-Serriah et al, 19 Boyne, 29,101 Busuttil Naudi et al, 30 and Toriumi et al 97 may give a good general impression of the effectiveness of rhBMPs regarding the quantity as well as quality of induced bone for the reconstruction of continuity mandibular defects (Details can be found in Addendum No.…”