Reconstruction of the human median nerve in the forearm with the Neurotube™

Donoghoe, B S Nicholas; Rosson, Gedge D.; Dellon, A. Lee

doi:10.1002/micr.20408

Cited by 70 publications

(38 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other researchers also compared PGA conduits and vein grafts to repair digital nerve gaps up to 4 cm and equivalent or superior recovery was obtained [146,147]. Further experiments have demonstrated the success of bioabsorbable PGA nerve conduits in the regeneration of nerve defects [148][149][150][151]. The most recent FDA-approved PGA conduit is Nerbridge ® , from Toyobo Co., Ltd., which is a flexible, semipermeable tubular membrane filled with porous Type I and III collagens ( Table 2).…”

Section: Polyglycolic Acidmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

show abstract

Section: Polyglycolic Acidmentioning

confidence: 99%

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Pedrosa¹,

Caseiro²,

Santos³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

show abstract

“…Usage of ANGs, however, leads to considerable donor side morbidity. Therefore, autologous muscle‐in‐vein grafts (MVGs), leading only to minor donor side morbidity (Manoli, Schulz, Stahl, Jaminet, & Schaller, 2014), represent promising alternative digital nerve grafts (Manoli, Schulz, et al., 2014; Marcoccio & Vigasio, 2010; Tos, Battiston, Ciclamini, Geuna, & Artiaco, 2012) as do several clinically approved biodegradable nerve guidance conduits (NGCs) (Bertleff, Meek, & Nicolai, 2005; Donoghoe, Rosson, & Dellon, 2007; Lohmeyer, Siemers, Machens, & Mailander, 2009; Meyer et al., 2016). …”

Section: Introductionmentioning

confidence: 99%

Reflex‐based grasping, skilled forelimb reaching, and electrodiagnostic evaluation for comprehensive analysis of functional recovery—The 7‐mm rat median nerve gap repair model revisited

2017

View full text Add to dashboard Cite

IntroductionThe rat median nerve injury and repair model gets increasingly important for research on novel bioartificial nerve grafts. It allows follow‐up evaluation of the recovery of the forepaw functional ability with several sensitive techniques. The reflex‐based grasping test, the skilled forelimb reaching staircase test, as well as electrodiagnostic recordings have been described useful in this context. Currently, no standard values exist, however, for comparison or comprehensive correlation of results obtained in each of the three methods after nerve gap repair in adult rats.MethodsHere, we bilaterally reconstructed 7‐mm median nerve gaps with autologous nerve grafts (ANG) or autologous muscle‐in‐vein grafts (MVG), respectively. During 8 and 12 weeks of observation, functional recovery of each paw was separately monitored using the grasping test (weekly), the staircase test, and noninvasive electrophysiological recordings from the thenar muscles (both every 4 weeks). Evaluation was completed by histomorphometrical analyses at 8 and 12 weeks postsurgery.ResultsThe comprehensive evaluation detected a significant difference in the recovery of forepaw functional motor ability between the ANG and MVG groups. The correlation between the different functional tests evaluated precisely displayed the recovery of distinct levels of forepaw functional ability over time.ConclusionThus, this multimodal evaluation model represents a valuable preclinical model for peripheral nerve reconstruction approaches.

show abstract

“…24 For any wider gap, however, the few reports of successful repair using conduits are confined to case reports. 35,36 Mackinnon (who is co-developer of the PGA conduit) recently reported on 4 cases of failed conduit-based major nerve reconstructions. 37 A recent addition to the armamentarium of the nerve surgeon, processed nerve allograft, may hold great promise for overcoming small gaps.…”

mentioning

confidence: 98%