Reconstruction of lateral through and through oro‐mandibular defects following oncological resections

Bianchi, Bernardo; Ferri, Andrea; Ferrari, Silvano; Copelli, Chiara; Boni, Pietro; Baj, A.; Sesenna, Enrico

doi:10.1002/micr.20786

Cited by 35 publications

(31 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 Our present results indicate that the iliac crest osteocutaneous flap by itself has a limited role in modern mandibular reconstruction. However, considering the many favorable properties of the iliac crest for mandibular reconstruction, including a natural curvature resembling that of the mandible, sufficient bone stock, and a concealable donor site, [10][11][12] the use of the flap in combination with another skin flap can be a useful option for selected patients. We believe that the skin island of the iliac crest flap should not be used for intraoral lining, unless adequate circulation of the skin island can be confirmed after inset.…”

Section: Discussionmentioning

confidence: 99%

Current role of the iliac crest flap in mandibular reconstruction

et al. 2011

View full text Add to dashboard Cite

The purpose of this study was to examine the current role of the iliac crest osteocutaneous flap in mandibular reconstruction, with a focus on the reliability of its skin island. We reviewed outcomes in 18 cases of immediate mandibular reconstruction with the iliac crest flap. Intraoral mucosal defects were closed with the skin island of the iliac crest flap in 13 patients (iliac crest flap group) and were closed with another free flap, because of poor circulation of the iliac crest skin island, in five patients (double-flap group). Postoperative results were poor in the iliac crest flap group. The rate of partial or total loss of the skin island was 46.2% in the iliac crest flap group and 20.0% in the double-flap group. The presence of a dominant perforator did not reduce the overall rate of recipient-site complications or reoperation. Combined use of another skin flap for intraoral lining provided better results. These results suggest that the skin island of the iliac crest flap should not be used for intraoral lining, unless adequate circulation of the skin island can be confirmed. If the circulation is questionable, combined use of another skin flap is strongly recommended.

show abstract

Section: Discussionmentioning

confidence: 99%

Current role of the iliac crest flap in mandibular reconstruction

et al. 2011

View full text Add to dashboard Cite

show abstract

“…25 When bone reconstruction is not indicated, we prefer a free ALT musculocutaneous flap, alone or in association with a titanium reconstructive plate. 26 In such cases, the muscular component of the flap plays a major role, it protects the plate with a large amount of well revascularized tissue, thereby preventing plate infections and exposure, while simultaneously providing bulky reconstruction of the defect and reducing the asymmetry of the oral cavity resulting from the mandibular resection. In the patients list reported here, any of the 12 plates used in association with the flap underwent exposure and esthetically, the bulk of the flap allowed an adequate facial contour restoration also when the flap was used alone (n 5 5).…”

Section: Discussionmentioning

confidence: 99%

The free anterolateral thigh musculocutaneous flap for head and neck reconstruction: One surgeon's experience in 92 cases

et al. 2012

Self Cite

View full text Add to dashboard Cite

The free ALT musculocutaneous flap offers unique advantages in head and neck reconstructions including adequate bulk when needed, obliteration of dead space, support for the soft tissues of the face, low donor-site morbidity, and harvesting without needing for perforators dissection, allowing for optimal patient outcome. Excessive bulky and thickness of subcutaneous tissue, especially in occidental population, have to be considered as the main disadvantages of this technique, finally the high incidence of hairy skin in thigh area in male patients and donor site scars associated with the use of skin grafts have to be considered as supplementary minor drawbacks.

show abstract

“…Despite the development of surgical techniques and prosthetic repair, defects in the facial structures lead to severe aesthetic and functional problems (1)(2)(3)(4). Uncontrollable and persistent loco-regional and distant recurrences with invasive disposition result in a low overall long-term survival rate.…”

Section: Introductionmentioning

confidence: 99%

Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma

2015

View full text Add to dashboard Cite

Abstract. Tumor development and progression are multistep processes that involve local tumor growth and invasion, followed by metastasis. The aggressiveness of the tumor is the major determinant of the mortality of oral cancer patients. The present study investigates whether the expression levels of cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), peroxiredoxin 1 (PRDX1) and PRDX6 are associated with the development, proliferation, differentiation and recurrence of oral squamous cell carcinoma (OSCC). The mRNA expression levels of COX-2, NF-κB, PRDX1 and PRDX6 were examined in 50 OSCC specimens and 19 normal oral mucosae by quantitative polymerase chain reaction (qPCR). qPCR analysis showed that the mRNA levels of COX-2 in OSCC were significantly higher than those in the normal oral mucosae (P=0.021). The expression levels of PRDX1 in high-stage tumors (T3 and T4) were significantly elevated compared with those in low-stage tumors (T1) (P=0.047). Additionally, the expression levels of NF-κB in the high-grade tumor were significantly elevated compared with those in the low-grade tumors (P=0.030). Overall, it was indicated that the expression of COX-2 is strongly associated with the development of OSCC. Moreover, the enhanced expression of PRDX1 and NF-κB may function in the progression of OSCC, which serves as a useful marker for prognosis in patients with oral cancer.

show abstract

Reconstruction of lateral through and through oro‐mandibular defects following oncological resections

Cited by 35 publications

References 33 publications

Current role of the iliac crest flap in mandibular reconstruction

Current role of the iliac crest flap in mandibular reconstruction

The free anterolateral thigh musculocutaneous flap for head and neck reconstruction: One surgeon's experience in 92 cases

Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma

Contact Info

Product

Resources

About