Reconstruction of human maxillary defects with nacre powder: histological evidence for bone regeneration

Atlan, G; Balmain, N.; Berland, Sophie; Vidal, B.; Lopez, Évelyne

doi:10.1016/s0764-4469(97)86933-8

Cited by 111 publications

(87 citation statements)

References 14 publications

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“…In previous studies (Atlan et al, 1997;Silve et al, 1992), as reviewed in Westbroek and Marin (1998) Shen et al (2006) have demonstrated the in vitro osteogenic activity of pearl. Hydroxyapatite can be formed on pearl surface in Simulated Body Fluid based on a dissolution-binding-precipitation mechanism.…”

Section: Biological Action Of Raw Nacrementioning

confidence: 92%

“…Over a period of 12 months, the nacre blocks show persistence without alteration of the implant shape. A complete sequence of osteogenesis resulted from direct contact between newly formed bone and the nacre, anchoring the nacre implant (Atlan et al, 1997). Furthermore, when nacre is implanted in bone, new bone formation occurs, without any inflammatory reaction and fibrous formation.…”

Section: Biological Action Of Raw Nacrementioning

confidence: 99%

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Nacre, a Natural Biomaterial

Rousseau¹

2011

Biomaterials Applications for Nanomedicine

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Section: Biological Action Of Raw Nacrementioning

confidence: 92%

Section: Biological Action Of Raw Nacrementioning

confidence: 99%

Nacre, a Natural Biomaterial

Rousseau¹

2011

Biomaterials Applications for Nanomedicine

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“…In mollusc shells, the aragonite and the protein matrix form a composite material (mineral matrix + organic matrix) called nacre. Taking into account that the mechanisms behind the construction of the different biomineralized tissues occur in similar fashion, it seems coherent to seek out materials that can substitute or induce the regeneration of bone tissue in other biomineralizing organisms, and this explains the attention given to corals and molluscs with shells 5,6,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] . Thus, this work has sought, through the gathering and comparison of the characteristics of clinical interest, to find in the residues from malacoculture the potential for obtaining an industrial input of low ecological/economic impact.…”

Section: Introductionmentioning

confidence: 99%

“…Nacre and biogenic aragonite are two materials of 25 , without inflammation and/or fibrous formations. In vivo and in vitro studies indicate the nacre as a biocompatible, biodegradable and osteocondutive material, which may attract and activate bone marrow stem cells and osteoblasts; the same was observed in biogenic aragonite [22][23][24][25][26][27][28][29][30][31][32][33][34][35] . The mechanical and tribological properties -as tensile, compression and bending strength, besides resistance to abrasion -of the nacre, comparatively better than that of pure aragonite, are due to its hierarchical structure of micrometric hexagonal tablets with mineral bridges and interlocking surfaces 36,[38][39][40][41][42] and cemented in organic matrix.…”

Section: Introductionmentioning

confidence: 99%

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Almeida¹,

Silva²,

Nakamura³

et al. 2015

Mat. Res.

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Aragonite is a metastable polymorph of calcium carbonate found in mollusk's shells, appearing in tiles and prismatic columns, cemented in a protein matrix -mainly proteins -that acts as a framework on which the aragonite is nucleated forming nacre, besides selecting the morphology of the nucleated cristaline phase. The presence of the mineralyzing organic matrix may affect osteoinductive properties of biogenic aragonite, hypothesis tested by combinated tests, comparing viability and bioactivity of biomineralizated aragonite and nacre. Bioactivity was observed by deposition of Ca-P (presumably calcium phosphate) on the surface of samples immersed in Simulated Body Fluid; biocompatibility was verified by adhesion with VERO cells; cytotoxicity and alkaline phosphatase activity assays were performed with human adipose stem cells (hASC). Samples were characterized by scanning electron microscopy and X-ray diffraction. Both materials showed similar behaviour on bioactivity assay; in contrast, exhibited different behaviours in the presence of hASC.

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“…Nacre is able to form a tight bond of bone without soft and fibrous tissue formation. It is gradually and centripetally dissolved but not resorbed by cells because it is not porous [141,142].…”

Section: Biopolymer-bioceramicsmentioning

confidence: 99%

Natural Products: A Minefield of Biomaterials

Ige

Umoru

Aribo

2012

ISRN Materials Science

147

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The development of natural biomaterials is not regarded as a new area of science, but has existed for centuries. The use of natural products as a biomaterial is currently undergoing a renaissance in the biomedical field. The major limitations of natural biomaterials are due to the immunogenic response that can occur following implantation and the lot-to-lot variability in molecular structure associated with animal sourcing. The chemical stability and biocompatibility of natural products in the body greatly accounts for their utilization in recent times. The paper succinctly defines biomaterials in terms of natural products and also that natural products as materials in biomedical fields are considerably versatile and promising. The various types of natural products and forms of biomaterials are highlighted. Three main areas of applications of natural products as materials in medicine are described, namely, wound management products, drug delivery systems, and tissue engineering. This paper presents a brief history of natural products as biomaterials, various types of natural biomaterials, properties, demand and economic importance, and the area of application of natural biomaterials in recent times.

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Reconstruction of human maxillary defects with nacre powder: histological evidence for bone regeneration

Cited by 111 publications

References 14 publications

Nacre, a Natural Biomaterial

Nacre, a Natural Biomaterial

Nacre Compared to Aragonite as a Bone Substitute: Evaluation of Bioactivity and Biocompatibility

Natural Products: A Minefield of Biomaterials

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