Reconstruction of circumferential pharyngoesophageal defects with laryngotracheal flap and pectoralis major myocutaneous flap

Chu, Pen–Yuan; Chang, Shun‐Hsyung

doi:10.1002/hed.10149

Cited by 21 publications

(13 citation statements)

References 22 publications

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“…Patients were assigned into two groups (before and after introduction of LTF) to facilitate comparison of nononcologic and oncologic results. The surgical technique of LTF reconstruction has been described in our previous reports7, 8 and is summarized in the following.…”

Section: Methodsmentioning

confidence: 99%

Reconstruction after resection of hypopharyngeal carcinoma: Comparison of the postoperative complications and oncologic results of different methods

Chu

Chang

2005

Head Neck

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Section: Methodsmentioning

confidence: 99%

Reconstruction after resection of hypopharyngeal carcinoma: Comparison of the postoperative complications and oncologic results of different methods

Chu

Chang

2005

Head Neck

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“…10 Complications like pharyngeal leakage, infection and the limited vascular anastomosis are to be resolved. 11 Recently, tissue engineering techniques for several tissues and organs have been introduced in experimental studies. Recent advances in tissue engineering and regenerative medicine have established a foundation on which the functional replacement of whole organs and complex tissues such as skeletal muscle, trachea, and esophagus seems possible.…”

Section: Introductionmentioning

confidence: 99%

Surface modification of polyurethane towards promoting the ex vivo cytocompatibility and in vivo biocompatibility for hypopharyngeal tissue engineering

et al. 2012

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Polymeric substrates with good biocompatibility have been widely employed to create a living construct with the complexities of tissue histology and function in the field of tissue engineering. In this study, poly(ester-urethane) (58213, NAT022) was used to be substrate due to its good physical and chemical properties. Proteins like gelatin or silk fibroin were covalently bonded on its surface using method of diamine aminolysis and glutaraldehyde crosslinking, which had been setup in our group in order to improve poly(ester-urethane)'s hydrophilicity and biocompatibility. The modification was proved by the measurements of static and dynamic contact angles and fluorescence detection. The biological properties were evaluated as in vitro cell culture and in vivo transplantation via cell number counting, morphology observation, immunohistochemistry analysis, etc. The results showed that gelatin or silk fibroin grafted membrane displayed good cytocompatibility, i.e. good proliferation and differentiation of human hypopharynx fibroblast and skeletal muscle cell though the control poly(ester-urethane) indicated low toxicity to cells and good biocompatibility, which was also verified in in vivo experiment. After poly(ester-urethane)-silk fibroin was implanted subcutaneously in rat back, it exhibited a better compatibility to peripheral tissue and faster biodegradation than the control poly(ester-urethane) did. This information supplied us valuable knowledge for poly(ester-urethane) to be used as matrix in situ hypopharynx regeneration study.

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“…Although PMMC flap reconstruction has been described a long time ago by Ariyan [6], its role cannot be denied in spite of the universal use of the free flaps in the past decade [7][8][9]. It's because of the ease of harvesting the flap with the abundant availability of both the skin and soft tissue for the reconstruction of a large defect in the oral cavity Fig.…”

Section: Discussionmentioning

confidence: 99%

Pectoralis Major Myocutaneous Flap for the Reconstruction of the Palatal Defect

Pradhan

Samal

Preetam

2018

Indian J Otolaryngol Head Neck Surg

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It is always a challenge for the soft tissue reconstruction of the palatal defects in advanced malignancies of the oral cavity because of the higher chance flap failure. PMMC flap can be successfully used in patients with advanced malignancies to repair the palatal defect without any significant postoperative complication. In the present case, we have presented a case of malignant melanoma of gingivobuccal complex, involving the hard palate where the palatal defect was successfully reconstructed by the PMMC flap.

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Reconstruction of circumferential pharyngoesophageal defects with laryngotracheal flap and pectoralis major myocutaneous flap

Abstract: The preliminary result shows this technique is a simple and effective method with low morbidity and satisfactory oncologic and functional results.

Cited by 21 publications

References 22 publications

Reconstruction after resection of hypopharyngeal carcinoma: Comparison of the postoperative complications and oncologic results of different methods

Reconstruction after resection of hypopharyngeal carcinoma: Comparison of the postoperative complications and oncologic results of different methods

Surface modification of polyurethane towards promoting the ex vivo cytocompatibility and in vivo biocompatibility for hypopharyngeal tissue engineering

Pectoralis Major Myocutaneous Flap for the Reconstruction of the Palatal Defect

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