Reconstruction of Anterior Tracheal Defects Using a Bioengineered Graft in a Porcine Model

Al-Ayoubi, Adnan M.; Rehmani, Sadiq; Sinclair, Catherine F.; Lebovics, Robert S.; Bhora, Faiz Y.

doi:10.1016/j.athoracsur.2016.10.034

Cited by 15 publications

(16 citation statements)

References 30 publications

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“…Heatmap representing the proportion of publications by year that utilized specific translational research methodologies from construct characterization to human trial to investigate laryngeal tissue engineering 85‐87,91,92,94,96,97,198‐306 …”

Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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While tissue engineering holds significant potential to address current limitations in reconstructive surgery of the head and neck, few constructs have made their way into routine clinical use. In this review, we aim to appraise the state of head and neck tissue engineering over the past five years, with a specific focus on otologic, nasal, craniofacial bone, and laryngotracheal applications. A comprehensive scoping search of the PubMed database was performed and over 2000 article hits were returned with 290 articles included in the final review. These publications have addressed the hallmark characteristics of tissue engineering (cellular source, scaffold, and growth signaling) for head and neck anatomical sites. While there have been promising reports of effective tissue engineered interventions in small groups of human patients, the majority of research remains constrained to in vitro and in vivo studies aimed at furthering the understanding of the biological processes involved in tissue engineering. Further, differences in functional and cosmetic properties of the ear, nose, airway, and craniofacial bone affect the emphasis of investigation at each site. While otolaryngologists currently play a role in tissue engineering translational research, continued multidisciplinary efforts will likely be required to push the state of translation towards tissue‐engineered constructs available for routine clinical use. Level of Evidence NA.

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Section: Discussionmentioning

confidence: 99%

Tissue engineering applications in otolaryngology—The state of translation

Niermeyer

Rodman

et al. 2020

Laryngoscope Investig Oto

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“…In addition, KD patients are generally younger, and there is the possibility of retrograde type A aortic dissection during long-term follow-up. Rosu et al 5 ) reported hybrid repair of KD. They concluded that in cases of severe arch angulation and short inner curve of the arch, proximal landing in the ascending aorta with total debranching of the neck vessels was a good procedure.…”

Section: Discussionmentioning

confidence: 99%

Single-Stage Surgical Repair of Kommerell Diverticulum with Annuloaortic Ectasia via a Median Sternotomy: Frozen Elephant Trunk Technique with an Antler-Like Shape Reconstruction of Arch Branches

Yamane

Furukawa

Yamada

2018

Annals of Vascular Diseases

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We present here a case of Kommerell diverticulum (KD) with annuloaortic ectasia, in which single-stage surgical repair was performed via a median sternotomy using frozen elephant trunk (FET) technique. We used this technique for the following reasons: firstly, we could perform surgery only via a median sternotomy without thoracotomy; secondly, we were able to deliver the FET using a guidewire through the severely angulated aortic arch. We here investigate this technique as it could potentially be a good treatment option of KD.

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“…The surgical procedure and tracheal replacement were performed as previously described [36]. Briefly, the animals were sedated and intubated with an 8-mm endotracheal tube, then placed supine on the operating table.…”

Section: Tracheal Graft Transplantationmentioning

confidence: 99%

“…ECM was important for graft integration with the native trachea and provided a substratum for mucosal coverage, epithelialization, and cellular recruitment [20]. We based this assumption on our previously published study in which we show that ECM allows mucosal coverage and epithelialization of the graft as well as provides an air-tight seal [36].…”

Section: Commentmentioning

confidence: 99%