Reconstruction of a 4-cm Human Median Nerve Gap by Including an Autogenous Nerve Slice in a Bioabsorbable Nerve Conduit: Case Report

Meek, Marcel F.; Fresow, Roel N. G. M.; Hawinkels, Harm

doi:10.1016/j.jhsa.2008.05.014

Cited by 4 publications

(3 citation statements)

References 2 publications

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“…Autologous nerve graft is considered to be the golden standard treatment after peripheral nerve injury (Meek et al, ; Payne Jr., ). However, donor tissue availability and being sacrificed, the need for additional incisions, and the risk of neuroma formation impose the major challenges.…”

Section: Discussionmentioning

confidence: 99%

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Repair of facial nerve crush injury in rabbits using collagen plus basic fibroblast growth factor

Wang

Zhao

Yao

et al. 2020

J Biomedical Materials Res

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Facial nerves are frequently crushed or cut during facial surgery. In this study, the feasibility of repairing facial nerves in rabbits after crush or cut off injury was evaluated using collagen conduits with A collagen‐binding domain (CBD)‐human basic fibroblast growth factor (bFGF). A total of 39 six‐month‐old New Zealand White rabbits were randomly divided into four groups of nine rabbits, and bilateral crush or cut off injuries were made on each animal's face. Three rabbits were classified as the healthy control. The facial nerves were cut or crushed and then were either untreated or wrapped with a collagen conduit plus bFGF. At the 15, 30, and 90 days after the injury, three rabbits in each group were sacrificed. Regeneration of the injured facial nerve was evaluated using electrophysiological examination (compound muscle action potentials, CAMPs), scanning electron microscopy, and histological observation. The results suggested that using collagen conduits with recombinant proteins CBD‐bFGF to repair facial nerves with crush or cut off injuries promoted functional facial nerve recovery. This treatment, as a possible therapeutic for patients with facial nerve injury, requires further investigation.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that the CBD could bind to native collagen in a saturable manner (Meek, Fresow, & Hawinkels, 2008). It is revealed that the fusion protein of CBD plus with bFGF is conducive to wound healing, probably because of its angiogenesis potential (Payne Jr., 2001).…”

Section: Introductionmentioning

confidence: 99%

Repair of facial nerve crush injury in rabbits using collagen plus basic fibroblast growth factor

Wang

Zhao

Yao

et al. 2020

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…2,3,9,10,25,28,35,41,44,46 A critical analysis of nerve gap lengths in which entubulation technology will no longer be successful has been performed in the laboratory. 12,13,17,20,29,32,45 More recently, it has been recognized that nerve diameter in addition to gap length may be a critical determinant in regeneration success, with largerdiameter nerves (for example, ulnar nerves) doing more poorly when compared with a small-diameter nerve (for example, digital nerve). 31 …”

confidence: 99%