Reconstructing the Glabella and Nasal Root

Neill, Brett C.; Rickstrew, Jace; Tolkachjov, Stanislav N.

doi:10.36849/jdd.6132

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Larger skin defects often impose a need for using different techniques for skin reconstruction [ 14 ]. One possibility is using advanced dressings for inducing faster secondary-intention healing [ 15 , 16 ] Possible alternatives include covering the wound surface through in vitro expanded epidermal sheets [ 17 ], skin grafts or flaps [ 18 , 19 ], and even the use of nanotechnologies [ 20 ], and/or stem-cell based therapies [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Wound Healing after Acellular Dermal Substitute Positioning in Dermato-Oncological Surgery: A Prospective Comparative Study

Paganelli

Naselli

Bertoni

et al. 2023

Life

View full text Add to dashboard Cite

Background: MatriDerm and Integra are both widely used collagenic acellular dermal matrices (ADMs) in the surgical setting, with similar characteristics in terms of healing time and clinical indication. The aim of the present study is to compare the two ADMs in terms of clinical and histological results in the setting of dermato-oncological surgery. Methods: Ten consecutive patients with medical indications to undergo surgical excision of skin cancers were treated with a 2-step procedure at our Dermatologic Surgery Unit. Immediately after tumor removal, both ADMs were positioned on the wound bed, one adjacent to the other. Closure through split-thickness skin grafting was performed after approximately 3 weeks. Conventional histology, immunostaining and ELISA assay were performed on cutaneous samples at different timepoints. Results: No significant differences were detected in terms of either final clinical outcomes or in extracellular matrix content of the neoformed dermis. However, Matriderm was observed to induce scar retraction more frequently. In contrast, Integra was shown to carry higher infectious risk and to be more slowly reabsorbed into the wound bed. Sometimes foreign body-like granulomatous reactions were also observed, especially in Integra samples. Conclusions: Even in the presence of subtle differences between the ADMs, comparable global outcomes were demonstrated after dermato-oncological surgery.

show abstract