Dendroclimatology and dendroecology have entered mainstream dendrochronology research in subtropical and tropical areas. Our study focused on the use of the chronology series of Masson pine (Pinus massoniana Lamb.), the most widely distributed tree species in the subtropical wet monsoon climate regions in China, to understand the tree growth response to ecological and hydroclimatic variability. The boosted regression trees (BRT) model, a nonlinear machine learning method, was used to explore the complex relationship between tree-ring growth and climate factors on a larger spatial scale. The common pattern of an asymptotic growth response to the climate indicated that the climate-growth relationship may be linear until a certain threshold. Once beyond this threshold, tree growth will be insensitive to some climate factors, after which a nonlinear relationship may occur. Spring and autumn climate factors are important controls of tree growth in most study areas. General circulation model (GCM) projections of future climates suggest that warming climates, especially temperatures in excess of those of the optimum growth threshold (as estimated by BRT), will be particularly threatening to the adaptation of Masson pine.