Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome

Andra, Syam S.; Austin, Christine; Wright, Robert O.; Arora, Manish

doi:10.1016/j.envint.2015.05.010

Cited by 47 publications

(40 citation statements)

References 48 publications

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“…This has recently been referred to as the ‘retrospective temporal exposome’ [12]. For health outcomes that occur at lower frequencies, this biomarker would be applied in population-based case-control designs.…”

Section: The Tooth Exposomementioning

confidence: 99%

“…The major limitation of the methodologies employed in these studies was to grind and analyze whole teeth (that constitutes the tissue and blood vessels within the pulp chamber) leading to exposure misclassification because of differential deposition of organic chemicals and contaminants in different tooth compartments. Andra and colleagues [12, 33] have demonstrated micro-spatial organic chemical measurements of specific growth rings in dentine that correspond to trimester-specific fetal developmental windows (Figure 1c). For example, mono-benzyl phthalate was quantified in dentine layers formed during the second and third trimester using liquid chromatography coupled tandem mass spectrometry (LC-MS/MS) targeted analysis [33].…”

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

“…The blood exposome was the first effort directed towards incorporating literature data for about 1600 exo- and endogenous chemicals into identifying associated metabolic pathways and disease etiologies [60]. Other emerging exposome approaches that consider measuring organics with distinct features are (a) tooth exposome that utilizes a novel bio-matrix, [12] (b) volatolomics that use a specific physical fraction (viz., exhaled breath or volatile organic compounds pool), [61, 62], and (c) pregnancy exposome that relies on collective data from multiple matrices and multiple sampling points during prenatal and child birth phase [63]. …”

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

“…Recently, we reconstructed the prenatal and early childhood exposure to multiple organic chemical classes using teeth [12]. We performed global screening of small molecules in trimester-specific formed dentine layers from deciduous teeth using liquid chromatography coupled quadrupole time-of-flight mass spectrometry (QTOF-LC/MS) metabolomics approach.…”

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

“…QTOFMS was operated in a dual electrospray ionization mode (positive and negative modes). Study design and results are presented in Andra et al [12]. Abbreviations for the chemicals on Y-axis: BPA, bisphenol A; MMP, mono-methyl phthalate; MEP, mono-ethyl phthalate; MBP, mono-nbutyl phthalate; MBzP, mono-benzyl phthalate; MEHP, mono-2-ethylhexyl phthalate; NIC, nicotine; COT, cotinine; HCOT, hydroxycotinine; BAP; bisphenol AP; BPF, bisphenol F; MP, methyl paraben; PP, propyl paraben; BP, butyl paraben; PFOA, pentadecafluorooctanoic acid; PFOS, perfluorooctanesulfonic acid; and DMP, dimethylphosphate.…”

Section: Figurementioning

confidence: 99%

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The tooth exposome in children's health research

Andra

Austin

Arora

2016

Current Opinion in Pediatrics

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Purpose of review The exposome concept proposes a comprehensive assessment of environmental exposures from the prenatal period onwards. However, determining exposure timing especially over the prenatal period is a major challenge in environmental epidemiologic studies. Recent findings For decades teeth have been used to estimate long-term cumulative exposure to metals. Recently developed high-dimensional analytical methods that combine sophisticated histological and chemical analysis to precisely sample tooth layers that correspond to specific life stages have the potential to reconstruct the exposome in the second and third trimesters of prenatal development and during early childhood. Summary A retrospective temporal exposomic approach that precisely measures exposure intensity and timing during prenatal and early childhood development would substantially aid epidemiologic investigations, particularly case–control studies of rare health outcomes.

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Section: The Tooth Exposomementioning

confidence: 99%

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

Section: Components Of the Exposome That Are Measurable In Tooth Matrmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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The tooth exposome in children's health research

Andra

Austin

Arora

2016

Current Opinion in Pediatrics

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Using primary teeth and archived dried spots for exposomic studies in children: Exploring new paths in the environmental epidemiology of pediatric cancer

et al. 2021

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It is estimated that 300,000 children 0-14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high-income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few wellestablished environmental risk factors for pediatric malignancies, likely due to technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene-environment interactions.

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