Reconstructing microvascular network skeletons from 3D images: what is the ground truth?
Claire Walsh,
Maxime Berg,
Hannah West
et al.
Abstract:Structural changes to microvascular networks are increasingly highlighted as markers of pathogenesis in a wide range of disease, e.g. Alzheimer’s disease, vascular dementia and tumour growth. This has motivated the development of dedicated 3D imaging techniques, alongside the creation of computational modelling frameworks capable of using 3D reconstructed networks to simulate functional behaviours such as blood flow or transport processes. Extraction of 3D networks from imaging data broadly consists of two ima… Show more
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