Reconstitution of cytolinker-mediated crosstalk between actin and vimentin
Irene Istúriz Petitjean,
Quang D. Tran,
Angeliki Goutou
et al.
Abstract:Cell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The biophysical properties of each filament type individually have been studied extensively by cell-free reconstitution. By contrast, the interactions between the three cytoskeletal networks are relatively unexplored. They are coupled via crosslinkers of the plakin family such as plectin. These are challenging proteins for reconstitution because of their giant si… Show more
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