Reconstituted collagen nanoparticles, a novel drug carrier delivery system

El-Samaligy, Mohamed S.; Rohdewald, Peter

doi:10.1111/j.2042-7158.1983.tb04831.x

Cited by 56 publications

(12 citation statements)

References 4 publications

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“…The difference in the degradation rate between the two enzymes suggests a degree of enzyme specificity. These results are in agreement with the data reported in the literature for collagen nanoparticles (19) and for gelatin nanoparticles where comparing to protease and α-chymotrypsin, trypsin appears to be the most suitable enzyme for gelatin nanoparticle degradation (7). The statistical analysis confirmed statistically significant difference at α = .05 in degradation rate among the series with different particle size in the presence of both enzymes.…”

Section: In Vitro Biodegradation Studies Of Gelatin Microspheressupporting

confidence: 91%

BSA - loaded gelatin microspheres: Comparative studies on biodegradation and drug release in presence of collagenase and trypsin

Mladenovska¹,

Janevic²,

Dodov³

et al. 2003

Maced. Pharm. Bull.

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Certain variations in the process parameters (emulsification time, surfactant concentration) were performed in order to prepare BSA-loaded gelatin microspheres with particle size ranging from 1 to 10 µm and high loading efficiency using a procedure originally employed by Tabata and Ikada. In vitro degradation and drug release studies in the presence of trypsin and collagenase, respectively, were performed in order to evaluate the potential of gelatin microspheres as regulated and sustained release systems for oral vaccination. Degradation data showed that the preparation procedure had provided prolonged degradation in the presence of both enzymes, suggesting complete in vivo degradation. Exponential dependence of the amount of drug released on time was evidenced. The diffusion coefficients were superior to 0.5 indicating the Case II anomalous Fickian diffusion, except for the particles smaller than 5 µm where in the presence of collagenase the transition to Super Case II transport was observed due to the higher rate of polymer degradation and BSA diffusion through the matrix. The mathematical modeling of drug release showed a biphasic release pattern in the presence of both enzymes, where the rate constants for the initial time release confirmed the influence of the particle size and/or enzymatic degradation rate on the drug release rate.

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Section: In Vitro Biodegradation Studies Of Gelatin Microspheressupporting

confidence: 91%

BSA - loaded gelatin microspheres: Comparative studies on biodegradation and drug release in presence of collagenase and trypsin

Mladenovska¹,

Janevic²,

Dodov³

et al. 2003

Maced. Pharm. Bull.

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“…Polymeric nanoparticles are colloidal solid particles prepared from biodegradable polymers such as chitosan and collagen or non-biodegradable polymers such as poly(lactic acid) (PLA) and poly(lactic co-glycolic acid) (PLGA) [9,12,13,14,15]. Their small size (50–300 nm) allows these particles to penetrate capillaries and to be taken up by the cells, increasing the accumulation of the drug at the target site of action [9].…”

Section: Common Nanoparticles Used In Cancer Medicinementioning

confidence: 99%

Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes

2013

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Nanomedicine is a growing research field dealing with the creation and manipulation of materials at a nanometer scale for the better treatment, diagnosis and imaging of diseases. In cancer medicine, the use of nanoparticles as drug delivery systems has advanced the bioavailability, in vivo stability, intestinal absorption, solubility, sustained and targeted delivery, and therapeutic effectiveness of several anticancer agents. The expansion of novel nanoparticles for drug delivery is an exciting and challenging research filed, in particular for the delivery of emerging cancer therapies, including small interference RNA (siRNA) and microRNA (miRNAs)-based molecules. In this review, we focus on the currently available drug delivery systems for anticancer agents. In addition, we will discuss the promising use of nanoparticles for novel cancer treatment strategies.

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“…This work laid the foundation for the development of doxorubicin-loaded NPs that were tested in clinical trials in the mid-1980s [157]. Polymeric NPs can be made from both synthetic polymers and natural polymers and may be used to encapsulate drugs without chemical modification [158][159][160]. The drugs can be released in a controlled manner through surface or bulk erosion, diffusion through the polymer matrix, swelling followed by diffusion, or in response to the local environmental change.…”

Section: Responsive Polymer-inorganic Hybrid Nanogels In Drug Deliverymentioning

confidence: 99%

Responsive Polymer‐Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery

Wu¹,

Zhou²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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Responsive hybrid nanogels, comprising inorganic nanoparticles (NPs) immobilized in a polymer nanogel, have recently attracted intensive interest. While inorganic NPs exhibit size-, shape-, and interdistance-dependent optical, magnetic, electronic, and catalytic properties, responsive polymer nanogels can undergo a volume phase transition in response to external stimuli, such as temperature, pH, glucose level, light, and other stimulus, to modify the physicochemical environment of the inorganic NPs immobilized inside. The controllable properties of the responsive hybrid nanogels can offer the possibilities for external switching and manipulation when applied to a diverse range of applications. In this Chapter we provide an analysis of recent advances on the responsive polymer-inorganic hybrid nanogels. The Chapter consists of three major parts: the fundamental theory, synthesis, and applications of the polymer-inorganic hybrid nanogels in optical sensing, diagnostic imaging, and drug delivery.

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Reconstituted collagen nanoparticles, a novel drug carrier delivery system

Cited by 56 publications

References 4 publications

BSA - loaded gelatin microspheres: Comparative studies on biodegradation and drug release in presence of collagenase and trypsin

BSA - loaded gelatin microspheres: Comparative studies on biodegradation and drug release in presence of collagenase and trypsin

Nanoparticles as Drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-Containing Nanoliposomes

Responsive Polymer‐Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery

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