Reconsidering an attenuated vaccine for AIDS

Beale, John

doi:10.1016/s0140-6736(96)90532-2

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Various vaccines are being tested against typhoid, cholera and rotavirus gastroenteritis [1,8], and considerable attention is being paid to a synthetic subunit vaccine for malaria [9]. Various HIV vaccines are being developed, and the recent isolation of apparently naturally attenuated mutants of HIV which lack the nef gene suggests they may be developed into attenuated vaccines [10].…”

Section: Modern Vaccinesmentioning

confidence: 99%

Two hundred years of vaccination

Baxby

1996

Current Biology

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accident'. Rather, a mechanism is proposed that could activate transcription of numerous genes in spermatids. If a gene is transcribed and its protein accumulates in spermatids, it is very possible that the protein will function there.Regulation of holoenzyme levels might also contribute to other cases of cell-type-specific gene regulation. Although no other cells seem to accumulate as much of the basal transcription machinery as early spermatids do, overall transcription rates do vary by more than an order of magnitude between different somatic tissue types [9]. Thus, differences in levels of the basal transcription machinery may be of wide-spread importance in determining patterns of cell-type-specific gene expression. References 1. Hecht NB: The making of a spermatozoon: a molecular perspective. Dev Genet 1995, 16:95-103. 2. Schmidt EE, Schibler U: High accumulation of components of the RNA polymerase II transcription machinery in rodent spermatids.

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Section: Modern Vaccinesmentioning

confidence: 99%