Late Cretaceous and early Tertiary volcanic and plutonic rocks in western Alaska comprise a vast magmatic province extending from the Alaska Range north to the Arctic Circle, south to Bristol Bay, and west to the Bering Sea Shelf. The chemical and isotopic composition of five of these Late Cretaceous to early Tertiary volcanic fields in the north central part of this province were studied to determine if Paleozoic or older continental crust underlies the Yukon‐Koyukuk province. Three of the fields, the Blackburn Hills, Yukon River, and Kanuti, occur within the Yukon‐Koyukuk province and two, the Sischu and Nowitna, overlie bordering Precambrian and Paleozoic metamorphic terranes to the southeast. High initial 87Sr/86Sr of 0.7075–0.7079 and moderate initial 143Nd/144Nd of 0.51244–0.51247 of rhyolite, dacite, and high‐silica andesite of the Sischu volcanic field indicate that the magmas have interacted with the underlying Paleozoic or older continental crust. The relatively limited variation of isotopic (initial 87Sr/86Sr = 0.7044–0.7051; initial 143Nd/144Nd = 0.51256–0.51257) and elemental compositions of andesites from the Nowitna field can be accounted for by assimilation of small amounts of Paleozoic or older continental crust during crystal fractionation of andesite parent magmas at crustal levels. The Blackburn Hills field, which consists of medium‐K basalt, andesite, and rhyolite intruded by a small granitic pluton, has a large range in initial 87Sr/86Sr and initial 143Nd/144Nd that plot in the field for 60 Ma mantle, from near mid‐ocean ridge basalts to near “bulk‐earth” compositions (initial 87Sr/86Sr = 0.7033–0.7052; initial 143Nd/144Nd = 0.51253–0.51290). Andesites and basalts from the Blackburn Hills are divided into two group on the basis of rare earth element (REE) and isotopic composition. Isotopic variation in the more primitive group 1 is best explained by assimilation of the lower crust of the Jurassic to Early Cretaceous Koyukuk terrane by mantle‐derived basalts during crystal fractionation, though part of the isotopic variation may be due to metasomatism of an oceanic island basalt type mantle source by fluids derived from subducted sediments. Group 2 andesites from the Blackburn Hills have lower heavy REE abundances and more enriched isotopic compositions. These group 2 andesites and dacites from the Kanuti field, which have (87Sr/86Sr)i = 0.7043–0.7048 and (143Nd/144Nd)i = 0.51248–0.51267, appear to have formed by partial melting of the lower crust of the Koyukuk terrane. The Yukon River field consists of basalt, andesite, dacite, and rhyolite having (87Sr/86Sr)i = 0.7037–0.7051 and (143Nd/144Nd)i = 0.51266–0.51280; its isotopic composition does not require the presence of Paleozoic or older continental crust under the volcanic field and may have formed by interaction between mantle‐derived melts and the oceanic Angayucham/Tozitna or island arc Koyukuk terrane. Most of the intrusive rocks and rhyolite domes from the Blackburn Hills volcanic field have (87Sr/86Sr)i = 0.7038–0.7041 and dacites f...
