Quantum computers are known to provide algorithmic speed ups over their classical counterparts 1 .In recent years, approaches based on various physical systems-superconducting qubits 2 , ion-trap systems 3 , and photonic systems 4,5 -have been extensively explored. However, constructing devices at scale required for real-world applications is no trivial task. Among the various approaches, measurementbased quantum computation 6,7 (MBQC) multiplexed in time domain 8 is currently a promising method for addressing the need for scalability. MBQC requires two components: cluster states and programmable measurements. With time-domain multiplexing, the former has been realized on an ultralarge-scale 9-12 . The latter, however, has remained unrealized, leaving the large-scale cluster states unused. In this work, we make such a measurement system and use it to demonstrate basic quantum operations multiplexed in the time-domain with 25 MHz clock frequency. This programmable mea-1