The AIS is an important component of the global climate system. Human activities have caused the atmosphere and especially the oceans to warm. However, the full effect of human caused climate change on the AIS has not currently been realised because the ice sheet responds on a range of timescales and to many different Earth processes. Modern observations show that West Antarctica has been melting at an accelerating rate since the 2000s, while the data for East Antarctica are less clear. Environmental records preserve the history of the climate and AIS, which extend beyond the instrumental record, and reveal how the AIS responded to past climate warming. Estimates of how much the AIS will contribute to sea-level rise by the year 2100 have changed as a result of new information on how the AIS evolved in the past, and research into the interactions between the ice sheet, solid Earthatmosphere and ocean systems. This review brings together our knowledge of the major processes and feedbacks affecting the AIS, and the evidence for how the ice sheet changed since the Pliocene. We consider the future estimates and consequences of global sea-level rise from melting of the AIS, and highlight priority research areas.