Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients

Chen, Ju; Lian, Qiaoyan; Zhang, Jianheng; Qiu, Tao; Cai, Zhitao; Jiang, Wenyang; Zhang, Jing; Cheng, Qi; Chen, Gang; Li, Ning; Wang, Chunyan; He, Jianxing

doi:10.1016/j.cdtm.2020.02.003

Cited by 23 publications

(37 citation statements)

References 28 publications

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“…The onset may be frequently early in the first postoperative months with unusual symptoms and rapid progression. Transplanted patients, usually, have a poorer prognosis compared to the general population, and moreover, molecular cross-reactivity after respiratory viral infection can determine an acute rejection in transplanted recipients [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

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[Retracted] COVID‐19 and Living Donor Kidney Transplantation in Naples during the Pandemic

Peluso

Campanile

Scotti

et al. 2020

BioMed Research International

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Introduction. SARS-CoV-2 is a virus that causes a potentially deadly syndrome that affects especially the respiratory tract. Kidney-transplanted patients are immunosuppressed and more susceptible to viral infections. We have examined our transplantation activity to explore the future role of kidney transplantation from deceased and living donors in COVID-19 era. Patients and Methods. The activity of our transplant center of Naples (one of the two transplant centers in Campania, South Italy) continued during the COVID-19 pandemic. We have analysed the kidney transplants carried out between March 9 and June 9, 2020, comparing these data with the numbers of procedures performed in the two previous years. Moreover, we have considered the possibility of performing living donor transplants during a worldwide pandemic. Results. From March 9, 2020, when the Italian lockdown begun, till June 9, 2020, five kidney transplants have been performed at our transplant center in Naples, all from deceased donors. The donors and the recipients have been screened for COVID-19 infection, and the patients, all asymptomatic, followed strict preventive measures and were fully informed about the risks of surgery and immunosuppression during a pandemic. All the transplanted patients remained COVID negative during the follow-up. The number of transplants performed has been constant compared to the same months of 2018 and 2019. In agreement with the patients, we decided to postpone living donor transplants to a period of greater control of the SARS-CoV-2 spread in Italy. Conclusion. Deceased donor kidney transplantation should continue, especially in a region with moderate risk, like Campania, with a more careful selection of donors and recipients, preferring standard donors and recipients without severe comorbidities. Living donor transplantation program, instead, should be postponed to a period of greater control of the SARS-CoV-2 spread, as it is an elective surgery and its delay does not determine additional risks for patients.

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Section: Discussionmentioning

confidence: 99%

“…fever, cough, dyspnoea to tracheitis-bronchitis, and pneumonia). The interest of the digestive tract is also characteristic [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] COVID‐19 and Living Donor Kidney Transplantation in Naples during the Pandemic

Peluso

Campanile

Scotti

et al. 2020

BioMed Research International

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“…[2][3][4] Given the evolving nature of the epidemic, knowledge about the epidemiology, clinical presentation, complications, and outcomes of COVID-19 in SOT patients has been drawn from case series, small multi-center observational studies, and expert discussion. [5][6][7][8][9][10][11][12] Though the clinical course has been reported to be mild in the majority of patients, 13 a higher likelihood of fulminant disease has been reported among patients who are elderly, immunocompromised, or have comorbidities. [14][15][16][17][18][19][20] As such, there is tremendous uncertainty among transplant programs about risks for SOT patients.…”

Section: Introductionmentioning

confidence: 99%

Evolving Impact of COVID‐19 on Transplant Center Practices and Policies in the United States

Boyarsky

Ruck

Chiang

et al. 2020

Clinical Transplantation

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COVID-19 has rapidly and dramatically impacted the entire healthcare system, and it has had a profound impact on the field of solid organ transplantation (SOT). In our first national survey of US transplant centers in March 2020, we found that more than 75% of kidney and liver transplant programs were either suspended or operating under major restrictions. 1 Programs reported concerns about shortages of critical supplies, including SARS-CoV-2 tests, ventilators, and personal protective equipment (PPE). There was widespread variation in testing practices, clinical practice, and patient management, which may have been partially driven by regional differences in the incidence of COVID-19. This was consistent with the nationwide

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“…The virus can be effectively inactivated under conditions of 56 °C for 30 min, using ether, 75% alcohol, chlorine-containing disinfectant, and chloroform. 3 Disinfection of HSCT wards should be performed with alcohol-containing disinfectants. People’s commute in the HSCT unit should be restricted as much as possible, and non-essential staff & student contact with inpatients should be reduced.…”

Section: Recommendationsmentioning

confidence: 99%

Guidance for Facing Dilemmas of Hematopoietic Stem Cell Transplant Clinicians in the Coronavirus Disease 2019 (COVID-19) Pandemic: An Iranian Consensus

Mousavi¹,

Rad²,

Rostami³

et al. 2020

Mediterr J Hematol Infect Dis

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Recommended prophylactic and management strategies for severe acute respiratory syndrome coronavirus 2 infection in transplant recipients

Cited by 23 publications

References 28 publications

[Retracted] COVID‐19 and Living Donor Kidney Transplantation in Naples during the Pandemic

[Retracted] COVID‐19 and Living Donor Kidney Transplantation in Naples during the Pandemic

Evolving Impact of COVID‐19 on Transplant Center Practices and Policies in the United States

Guidance for Facing Dilemmas of Hematopoietic Stem Cell Transplant Clinicians in the Coronavirus Disease 2019 (COVID-19) Pandemic: An Iranian Consensus

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