Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters

Abstract

An extensive series of evaluations have been performed as part of an IAEA coordinated research project to study a set of nuclear reactions that produce the diagnostic gamma-ray emitting radionuclides 51 Cr, 99m Tc, 111 In, 123 I and 201 Tl. Recommended cross-section data in the form of excitation functions have been derived, along with quantifications of their uncertainties. These evaluations involved the compilation of all previously published values and newly measured experimental data, followed by critical assessments and selection of those experimental datasets and accompanying uncertainties judged to be fully valid and statistically consistent for model-independent least-squares fitting by means of Padé approximations. Integral yields as a function of the energy were also calculated on the basis of the recommended cross sections deduced from these various fits. All evaluated numerical results and their corresponding uncertainties are available online at www-nds.iaea.org/medical/gamma_emitters.html and also on the medical portal of the International Atomic Energy Agency/Nuclear Data Section (IAEA-NDS) www-nds.iaea.org/medportal/.

Continuing Nuclear Data Research for Production of Accelerator-Based Novel Radionuclides for Medical Use: A Mini-Review

“…The first two were related to radionuclides commonly used in diagnosis (IAEA-TECDOC-1211, 2001) and internal therapy (IAEA-Technical Report-473, 2011). In the third CRP, some updates were done but also the production data of some novel radionuclides were standardized [6][7][8]. The initial work was rather empirical.…”

A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with 68Ga, 44Sc, 177Lu and 161Tb

“…It should be pointed out that the inherent success of any production strategy requires precise nuclear data [46][47][48]. Between 2012 and 2016, extensive nuclear data studies were carried within a research project, coordinated by the International Atomic Energy Agency (IAEA) consisting of compilation, evaluation, and recommendation of cross-section data for the production of medical radionuclides [49,50]. As a result, considerable extensions and valuable improvements have been made to the IAEA-NDS recommended cross-section database for the production of PET and gamma-emitting radionuclides.…”

Upgrade of recommended nuclear cross section data base for production of therapeutic radionuclides

“…The IAEA Nuclear Data Section has hence coordinated several actions to set up a database for recommended cross-sections and associated nuclear decay data for various charged-particle reactions used for medical radionuclides production over the last 25 years. The results of these evaluations were published in webpages of the IAEA-NDS and documented in [1][2][3][4][5][6][7] and at numerous conferences. For most of the reactions studied these evaluations resulted in recommended cross section data with uncertainties and production yield data.…”