Recommended dose for repair of serum vitamin A levels in patients with HIV infection/AIDS may be insufficient because of high urinary losses

Neves, Fábio Fernandes; Vannucchi, Hélio; Jordão, Alceu Afonso; Figueiredo, J F C

doi:10.1016/j.nut.2005.11.008

Cited by 8 publications

(6 citation statements)

References 52 publications

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“…Therefore, chronically low plasma retinol levels may reflect a presymptomatic stage of the disease, in which the person is less responsive to retinol supplementation. Increased retinol excretion in urine (Neves et al, 2006) has been shown as a mechanism to explain the failure of increase in plasma retinol levels with supplementation. Unfortunately it was not feasible to test this hypothesis, as retinol excretion was not measured in this study.…”

Section: Discussionmentioning

confidence: 99%

Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia

Alfonso¹,

Reid²,

Klerk³

et al. 2010

European Journal of Cancer Prevention

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Owing to the high rates of malignant mesothelioma in workers exposed to crocidolite earlier at Wittenoom and evidence of protection against cancer by vitamin A, a population-based cancer prevention programme providing retinol supplements (25 000 IU/day) was commenced in 1990. The former workers at Wittenoom known to be alive and living in Western Australia in June 1990 constitute the study population. The participants were classified into two groups: those who received supplemental retinol (intervention group) and those who received none (comparison group). The relative rate of mesothelioma for those receiving retinol was estimated using Cox regression, adjusting for cumulative asbestos exposure and age at first exposure to asbestos. Nine hundred and twenty-eight former Wittenoom workers received retinol at some stage of the programme, whereas 1471 workers never received retinol (comparison group). Those who received retinol were younger, had a greater exposure to asbestos and smoked less than the comparison group. There were 65 cases of mesothelioma in the retinol group and 88 in the comparison group. After adjustment, the hazard ratio was 0.99 (95% confidence interval=0.70-1.41). This result did not alter when the participants who received only retinol once or those who received beta-carotene earlier were excluded from the analysis. In conclusion, this study provides little support for possible preventive effects of retinol against mesothelioma in workers exposed to blue asbestos.

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Section: Discussionmentioning

confidence: 99%

Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia

Alfonso¹,

Reid²,

Klerk³

et al. 2010

European Journal of Cancer Prevention

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“…Além disso, os indivíduos com AIDS excretam mais vitamina A na urina que os pacientes apenas soropositivos, e estes últimos mais que os controles normais 13,14 . Provavelmente, a perda urinária deve-se à diminuição da capacidade do túbulo proximal de reabsorver proteínas de baixo peso molecular, como a RBP na vigência de elevada atividade inflamatória [15][16][17] .…”

Section: Resultsunclassified

“…Um trabalho experimental mostrou que a administração de lipopolissacarídeo de Pseudomonas aeruginosa leva à diminuição da transcrição do RNA mensageiro que codifica a síntese da RBP, mesmo com concentrações hepáticas normais de retinol 25 ; 2) durante a inflamação ocorre alteração da permeabilidade capilar com extravasamento de proteínas de baixo peso molecular para o terceiro espaço 26,27 . Diante desta situação patológica, o complexo RBP-retinol poderia deixar o meio intravascular, gerando uma redução temporária do retinol plasmático 28 , e finalmente; 3) a inflamação poderia levar ao aumento da perda urinária de RBP e retinol, reduzindo os níveis séricos desta vitamina 14,15,28 . Em resumo, este trabalho mostra que a proteína C reativa e o fator de necrose tumoral alfa correlacionam-se negativamente com as concentrações séricas de retinol e RBP, sugerindo um efeito direto da resposta de fase aguda sobre a biodisponibilidade destes nutrientes.…”

Section: Resultsunclassified

Influência da resposta inflamatória de fase aguda nos níveis séricos de retinol e da proteína de ligação do retinol em pacientes com AIDS

Neves

Figueiredo

Júnior

et al. 2010

Rev. Soc. Bras. Med. Trop.

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RESUMOIntrodução: A hiporretinolemia constitui fator prognóstico independente em pacientes com AIDS, e a atividade inflamatória causa redução dos níveis séricos deste nutriente na população em geral. Entretanto, faltam estudos que avaliem o impacto da atividade inflamatória sobre o nível sérico do retinol em pacientes com AIDS. Métodos: foram avaliados transversalmente 41 pacientes internados por complicações da AIDS, que tiveram quantificados alguns marcadores de inflamação (proteína C reativa e fator de necrose tumoral alfa) e concentrações séricas de retinol e da proteína de ligação do retinol. Resultados: Apesar da baixa (14,6%) prevalência de hiporretinolemia evidenciou-se correlação negativa dos marcadores de inflamação com os níveis séricos de retinol e de sua proteína de ligação nos pacientes com AIDS. Conclusões: a atividade inflamatória de fase aguda está associada a baixos níveis séricos de retinol em indivíduos com AIDS. Palavras-chaves: ABSTRACTIntroduction: Hyporetinolemia is an independent prognostic factor in AIDS patients. Inflammatory activity causes a reduction in the serum levels of this nutrient in the general population. However, there are no studies assessing the impact of inflammatory activity on the serum retinol level in AIDS patients. Methods: A cross-sectional assessment was conducted on 41 patients hospitalized due to AIDS complications. Inflammatory markers (C-reactive protein and tumor necrosis factor-alpha) and serum retinol and retinol binding protein concentrations were quantified. Results: Despite the low (14.6%) prevalence of hyporetinolemia, a significant negative correlation was observed between the inflammatory markers and the serum retinol and retinol binding protein levels in AIDS patients. Conclusions: Acute-phase inflammatory activity is associated with low serum retinol levels in individuals with AIDS.

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“…Retinol deficiency is quite frequent in the population of HIV-infected individuals. Serum retinol levels of less than 1.05 micromol/L determine a 3.5 to five times higher death risk 6. The recommended treatment for HIV-positive individuals is similar to their HIV-negative peers 5…”

Section: Discussionmentioning

confidence: 99%

An unusual ocular presentation of acquired immune deficiency syndrome

Arunachalam¹,

Hegde²,

Jain³

et al. 2008

Indian J Ophthalmol

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Recommended dose for repair of serum vitamin A levels in patients with HIV infection/AIDS may be insufficient because of high urinary losses

Cited by 8 publications

References 52 publications

Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia

Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia

Influência da resposta inflamatória de fase aguda nos níveis séricos de retinol e da proteína de ligação do retinol em pacientes com AIDS

An unusual ocular presentation of acquired immune deficiency syndrome

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