Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I.; Compston, A; Edan, Gilles; Goodkin, Donald E.; Hartung, Hans‐Peter; Lublin, Fred; McFarland, Henry F.; Paty, Donald W.; Polman, Chris H.; Reingold, Stephen C.; Sandberg‐Wollheim, Magnhild; Sibley, W. A.; Thompson, Alan J.; Noort, Stanley van den; Weinshenker, Brian; Wolinsky, Jerry S.

doi:10.1002/ana.1032

Cited by 6,159 publications

(4,371 citation statements)

References 23 publications

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“…An additional 22 subjects developed new MRI lesions and fulfilled International Panel criteria for radiographic dissemination over time. 10 10 CIS subjects were lost to follow-up and did not contribute to the long-term outcome data. 16 CIS subjects did not experience clinical or radiographic dissemination over time.…”

Section: Resultsmentioning

confidence: 99%

Long‐term evolution of multiple sclerosis disability in the treatment era

Team:

2016

Annals of Neurology

357

167

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Objectives To characterize the accrual of long-term disability in a cohort of actively treated multiple sclerosis (MS) patients and to assess whether clinical and MRI data used in clinical trials have long-term prognostic value. Methods This is a prospective study of 517 actively managed MS patients enrolled at a single center. Results More than 91% of patients were retained, with data ascertained up to 10 years after the baseline visit. At this last assessment, neurologic disability as measured by the Expanded Disability Status Score (EDSS) was stable or improved compared to baseline in 41% of patients. Subjects with no evidence of disease activity (NEDA) by clinical and MRI criteria during the first two years had long-term outcomes that were no different from those of the cohort as a whole. 25-OH vitamin D serum levels were inversely associated with short-term MS disease activity; however, these levels had no association with long-term disability. At a median time of 16.8 years after disease onset, 10.7% (95% CI 7.2 to 14%) of patients reached an EDSS ≥6 and 18.1% (95% CI: 13.5 to 22.5%) evolved from relapsing MS (RMS) to secondary progressive MS (SPMS). Interpretations Rates of worsening and evolution to SPMS were substantially lower when compared to earlier natural history studies. Notably, the NEDA 2-year endpoint was not a predictor of long-term stability. Finally, the data call into question the utility of annual MRI assessments as a treat-to-target approach for MS care.

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Section: Resultsmentioning

confidence: 99%

Long‐term evolution of multiple sclerosis disability in the treatment era

Team:

2016

Annals of Neurology

357

167

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“…Participants were randomized either to the intervention ( n = 40) or the control ( n = 40) group. Study inclusion criteria were a diagnosis of MS based on McDonald's criteria (McDonald et al., 2001), at least 6 months after diagnosis of the disease, between the ages of 20 and 45, able to speak and communicate in Persian, and able to read and write. Study exclusion criteria were having other acute or chronic physical disorders that might impede the intervention, severe visual or speech impairments, and being in the acute stages of MS. After obtaining informed consent, data were collected through administration of questionnaires.…”

Section: Methodsmentioning

confidence: 99%

Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis

et al. 2017

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ObjectivesMultiple sclerosis (MS) is a chronic and progressive disease that causes stress due to its unpredictability and lack of definitive treatments. This study examined the effects of an educational program using a transactional model to help women with MS cope with their disease.Materials and MethodsIn a randomized clinical trial, 80 female patients from the MS Society of Iran were randomized to the intervention (n = 40) or a control group (n = 40). Outcomes were assessed using Cohen's Perceived Stress Scale (PSS) and the Jalowiec Coping Scale (JCS), which were completed by both groups at baseline, 1 month, and 3 months after the intervention. The intervention consisted of six educational sessions administered over 2 months based on a transactional model. The data were analyzed using repeated measures ANOVA.ResultsAverage PSS scores decreased significantly over time in the intervention group, while increasing in the control group. Between‐group differences were significant at both 1‐month and 3‐month follow‐up (p < .001). Both problem‐focused and emotion‐focused coping styles improved over time in use and effectiveness in the intervention group, whereas little or no change occurred in these coping behaviors in the control group.ConclusionThe transactional model‐based education program tested here was successful in reducing stress levels and increasing healthy coping styles in women with MS. If these findings are replicated in future studies, widespread adoption of this program may help women with MS cope more successfully with their disease.

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“…(1983) or McDonald et al. (2001); Polman et al. (2011) criteria and we were able to detect course of the disease.…”

Section: Methodsmentioning

confidence: 99%

Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10‐year retrospective cohort study

et al. 2018

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ObjectivesMultiple sclerosis (MS) often occurs in young women and the effect of obstetric anesthesia/analgesia on the disease is poorly understood. No previous study has investigated the course of the disease in women in labor in the Czech Republic. The aim of this study was to evaluate the occurrence or absence of relapses in the 6‐month postpartum period in MS parturients with and without obstetric anesthesia/analgesia.Materials and MethodsWe retrospectively studied all deliveries (n = 58,455) at the University Hospital Brno from 2004 to 2013 and identified those of the women with an ICD‐10 code G35 (MS) recorded anytime in their medical history (n = 428). We included only deliveries of women with confirmed diagnosis at the time of labor (n = 70). Statistical analysis was performed using the Fischer Exact Test.ResultsThere were 70 deliveries of 65 women, including 45 vaginal deliveries and 25 Cesarean deliveries (16 under general anesthesia, 8 with epidural anesthesia and 1 with spinal anesthesia). Epidural obstetric analgesia was performed in 11 deliveries. There was no statistically significant difference in relapses between the vaginal delivery group (n = 15; 33%) and Cesarean section group (n = 10; 40%), p = 0.611.ConclusionNeither delivery mode (vaginal vs Caesarean) nor type of obstetric anesthesia/analgesia was found to have any impact on the course of MS at 6 months postpartum in women with this condition.

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Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

Cited by 6,159 publications

References 23 publications

Long‐term evolution of multiple sclerosis disability in the treatment era

Long‐term evolution of multiple sclerosis disability in the treatment era

Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis

Obstetric anesthesia/analgesia does not affect disease course in multiple sclerosis: 10‐year retrospective cohort study

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