Recommendations on the Use of Multiple Labels in Human Mass Balance Studies
Filip Cuyckens,
Mette G. Hvenegaard,
Kenneth C. Cassidy
et al.
Abstract:The administration of radiolabeled drug candidates is considered the gold standard in absorption, distribution, metabolism and excretion (ADME) studies for small molecule drugs, since it allows facile and accurate quantification of parent drug, metabolites and total drug related material independent of the compound structure. The choice of the position of the radiolabel, typically 14 C or 3 H, is critical to obtain relevant information. Sometimes a biotransformation reaction may lead to cleavage of a part of t… Show more
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