Recommendations for the reporting of prostate carcinoma

Epstein, Jonathan I.; Srigley, John R.; Grignon, David J.; Humphrey, Peter A.; Otis, Christopher

doi:10.1007/s00428-007-0441-4

Cited by 15 publications

(13 citation statements)

References 11 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, we propose that this parameter should also be reported and not only the number of positive nodes as recently recommended by the Association of Anatomic and Surgical Pathology. 33 Figure 4. Biochemical recurrence-free (A), disease-specific (B) and overall (C) survival stratified for the median diameter of the largest metastasis per patient (<6 mm versus ‡6 mm).…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in lymph node metastases of prostatic cancer patients: the size of the metastases but not extranodal extension independently predicts survival

Fleischmann¹,

Schobinger²,

Markwalder³

et al. 2008

Histopathology

View full text Add to dashboard Cite

ENE in prostatic cancer is an indicator lesion for advanced/aggressive tumours with poor outcome. However, the strong correlation with larger metastases suggests that ENE may result from their size, which was the only independent risk factor in the metastasizing component. Consequently, histopathological reports should specify the true indicator of poor survival in the lymphadenectomy specimens, which is the size of the largest metastasis in each patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic factors in lymph node metastases of prostatic cancer patients: the size of the metastases but not extranodal extension independently predicts survival

Fleischmann¹,

Schobinger²,

Markwalder³

et al. 2008

Histopathology

View full text Add to dashboard Cite

show abstract

“…The current literature does not support the usefulness of clinical markers (e.g. DRE, PSA level, PSA density or free PSA) in predicting which patients with HGPIN are more likely to progress to PCa [6]. Further investigation into the process of carcinogenetic transformation of HGPIN could be helpful in deciding which patients are at risk of progressing to PCa.…”

Section: Introductionmentioning

confidence: 87%

Low testosterone level predicts prostate cancer in re‐biopsy in patients with high grade prostatic intraepithelial neoplasia

et al. 2012

View full text Add to dashboard Cite

E 1 9 9What ' s known on the subject? and What does the study add? High grade prostatic intraepithelial neoplasia (HGPIN) is a risk factor for prostate cancer (PCa), but only multifocality is an indication for early rebiopsy. Other risk factors for PCa development from HGPIN remain unknown. PCa is related to testosterone. Testosterone has been proven to be linked to PCa detection and poor prognosis PCa.This study shows that low free and bioavailable testosterone levels are associated with an increased risk of PCa in a rebiopsy after HGPIN diagnosis. Men with low testosterone levels and HGPIN could therefore be considered a high-risk cohort for developing PCa. OBJECTIVE• To determine the relevance of the hormonal profi le of patients with high grade prostatic intraepithelial neoplasia (HGPIN) and its relationship to prostate cancer (PCa) in rebiopsy. • A comparative study between those patients with a positive rebiopsy and those with a negative rebiopsy was performed. PATIENTS AND METHODS • RESULTS• We found that free testosterone ( P = 0.04), bioavailable testosterone ( P = 0.04) and SHBG ( P = 0.02) were signifi cantly associated with a positive rebiopsy.• Other variables such as age ( P = 0.745), PSA level ( P = 0.630), prostate volume ( P = 0.690), PSA density ( P = 0.950), testosterone ( P = 0.981) and prostatic intraepithelial neoplasia multifocality ( P = 0.777) were not associated with the presence of adenocarcinoma in the rebiopsy. CONCLUSIONS• Patients with adenocarcinoma of the prostate after a diagnosis of HGPIN have higher SHBG levels and lower calculated free testosterone levels than patients with a negative rebiopsy.• Testosterone levels might be a useful indication for rebiopsy after HGPIN diagnosis. KEYWORDS rebiopsy , prostatic intraepithelial neoplasia , testosteroneStudy Type -Prognosis (case series) Level of Evidence 4

show abstract

“…The 6th edition of the International Union Against Cancer (UICC) TNM Classification [15] was used for staging. pT1: not palpable or visible tumors, pT2: organ confined tumors, pT3: tumors with extraprostatic extension (subcategories pT3a and pT3b for seminal vesicles infiltration were determined as recommended [20]), pT4: tumors invading adjacent structures including bladder neck. Accordingly, our patients with bladder neck infiltration were defined as pT4, although there is evidence that this staging should be revised because bladder neck infiltration is prognostically equivalent to pT3b disease [21].…”

Section: The Prostatementioning

confidence: 99%

Survival in surgically treated, nodal positive prostate cancer patients is predicted by histopathological characteristics of the primary tumor and its lymph node metastases

et al. 2008

View full text Add to dashboard Cite

The TNM classification's current allocation of only one category for nodal metastases in prostate cancers is unsatisfactory since subgroups with significantly different prognoses can be identified. The diameter of the patient's largest metastasis (< or =10 mm vs. >10 mm) should be used for substaging because of its independent prognostic value. The substage "micrometastasis only" is also useful in nodal positive prostate cancer since it designates the subgroup with the most favorable outcome.

show abstract

Recommendations for the reporting of prostate carcinoma

Cited by 15 publications

References 11 publications

Prognostic factors in lymph node metastases of prostatic cancer patients: the size of the metastases but not extranodal extension independently predicts survival

Prognostic factors in lymph node metastases of prostatic cancer patients: the size of the metastases but not extranodal extension independently predicts survival

Low testosterone level predicts prostate cancer in re‐biopsy in patients with high grade prostatic intraepithelial neoplasia

Survival in surgically treated, nodal positive prostate cancer patients is predicted by histopathological characteristics of the primary tumor and its lymph node metastases

Contact Info

Product

Resources

About