Recommendations for reporting adverse drug reactions and adverse events of traditional Chinese medicine

Wu, Taixiang; Shang, Hongcai; Bian, Zhaoxiang; Zhang, Junhua; Li, Ting-qian; Li, Youping; Zhang, Boli

doi:10.1111/j.1756-5391.2010.01056.x

Cited by 18 publications

(5 citation statements)

References 5 publications

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“…However, the applications may be largely dependent on the clinician’s experience, which may limit the application of same decoction by different clinicians to different patients. The condition may explain the frequently occurred adverse events in application of particular traditional medicine ( Wang et al, 2010 ; Wu et al, 2010 ; Hwang et al, 2018 ). Moreover, the bioactive ingredients of the decoctions have not been fully identified and studied in independent experiments.…”

Section: Limitations and Possible Solutionsmentioning

confidence: 99%

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

Xu,

Yao,

Liu

et al. 2023

Front. Pharmacol.

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Ulcerative colitis (UC) is an idiopathic inflammatory disease mainly affects the large bowel and the rectum. The pathogenesis of this disease has not been fully elucidated, while the disruption of the intestinal barrier function triggered by various stimulating factors related to the host genetics, immunity, gut microbiota, and environment has been considered to be major mechanisms that affect the development of UC. Given the limited effective therapies, the treatment of this disease is not ideal and its incidence and prevalence are increasing. Therefore, developing new therapies with high efficiency and efficacy is important for treating UC. Many recent studies disclosed that numerous herbal decoctions and natural compounds derived from traditional herbal medicine showed promising therapeutic activities in animal models of colitis and have gained increasing attention from scientists in the study of UC. Some of these decoctions and compounds can effectively alleviate colonic inflammation and relieve clinical symptoms in animal models of colitis via regulating intestinal barrier function. While no study is available to review the underlying mechanisms of these potential therapies in regulating the integrity and function of the intestinal barrier. This review aims to summarize the effects of various herbal decoctions or bioactive compounds on the severity of colonic inflammation via various mechanisms, mainly including regulating the production of tight junction proteins, mucins, the composition of gut microbiota and microbial-associated metabolites, the infiltration of inflammatory cells and mediators, and the oxidative stress in the gut. On this basis, we discussed the related regulators and the affected signaling pathways of the mentioned traditional medicine in modulating the disruption or restoration of the intestinal barrier, such as NF-κB/MAPK, PI3K, and HIF-1α signaling pathways. In addition, the possible limitations of current studies and a prospect for future investigation and development of new UC therapies are provided based on our knowledge and current understanding. This review may improve our understanding of the current progression in studies of traditional medicine-derived therapies in protecting the intestinal barrier function and their roles in alleviating animal models of UC. It may be beneficial to the work of researchers in both basic and translational studies of UC.

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Section: Limitations and Possible Solutionsmentioning

confidence: 99%

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

Xu,

Yao,

Liu

et al. 2023

Front. Pharmacol.

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“…Shuanghuanglian injection is usually used for the treatment of respiratory infection and has been one of the top selling herbal medicine products over the last decade 17 . However, Shuanghuanglian injection often causes severe allergic reaction in the clinic [18][19][20] . Recent study had shown that, the cosolvent Tween-80 in herbal injection is the main inducement of allergic reaction and the medical shock 21,22 .…”

Section: Determination Of 5-ht In Allergic Guinea Pig Plasmamentioning

confidence: 99%

Simultaneous Determination of Serotonin, b-Hexosaminidase and Histamine in Allergic Guinea Pigs Caused by Three Herbal Injections

Wang¹,

Xiao²,

Wang³

et al. 2014

Asian J. Chem.

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“…Problems concerning the choice and reporting of outcome measures for clinical trials of TCM were summarized as follows [ 5 , 8 – 10 ]. (1) Outcome measured and reported in clinical trials of the same condition varied greatly, and there was apparent selective reporting bias.…”

Section: Problems With Outcome Measures In Clinical Trials Of Tcmmentioning

confidence: 99%

Clinical Research of Traditional Chinese Medicine Needs to Develop Its Own System of Core Outcome Sets

Zhang

Chen

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Currently, quality issues concerning clinical research of traditional Chinese medicine (TCM) have come into the spotlight. It has been recognized that poorly-devised research methodology largely restricted the development of clinical research in TCM. The choice of appropriate outcome measurements is key to the success of clinical research; however, the current procedure for outcomes selection in clinical research of TCM is problematic due to the underdevelopment of clinical methodology. Under this circumstance, we propose the introduction to the concept of Core Outcome Set (COS) and discuss the feasibility of developing a COS system that caters for clinical studies in TCM, in the hope that the outcome evaluation system could be up to international standards.

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Recommendations for reporting adverse drug reactions and adverse events of traditional Chinese medicine

Cited by 18 publications

References 5 publications

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

The mechanism of traditional medicine in alleviating ulcerative colitis: regulating intestinal barrier function

Simultaneous Determination of Serotonin, b-Hexosaminidase and Histamine in Allergic Guinea Pigs Caused by Three Herbal Injections

Clinical Research of Traditional Chinese Medicine Needs to Develop Its Own System of Core Outcome Sets

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