Recommendations for Long-Term Follow-up of Adults with Heritable Retinoblastoma

Tonorezos, Emily S.; Friedman, Danielle Novetsky; Barnea, Dana; Bosscha, Machteld I.; Chantada, Guillermo; Dommering, Charlotte J.; Graaf, Pim de; Dunkel, Ira J.; Fabius, Armida W.M.; Francis, Jasmine H.; Greer, Mary‐Louise C.; Kleinerman, Ruth A.; Kors, Wijnanda A.; Laughlin, Suzanne; Moll, Annette C.; Morton, Lindsay M.; Temming, Petra; Tucker, Margaret A.; Leeuwen, Flora E. van; Walsh, Michael F.; Oeffinger, Kevin C.; Abramson, David H.

doi:10.1016/j.ophtha.2020.05.024

Cited by 28 publications

(21 citation statements)

References 85 publications

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“…Examples of SMN sites, with strong evidence of risk are bone and soft tissue (sarcomas), skin (melanomas), brain and spinal cord (CNS tumor). Also carcinomas and hematological malignancies are reported, although the evidence for these SMN sites is respectively moderate and weak [ 4 ].…”

Section: Smn Definition and Reason Of Susceptibility In Heritable mentioning

confidence: 99%

“…Published risk evidence for different types of SMNs in heritable Rb survivors was recently assessed by a panel of providers from over the world [ 4 ]. Heritable Rb survivors have significantly increased risks for sarcoma, melanoma and brain/CNS tumors, the latter only when radiotherapy was received for their Rb treatment.…”

Section: Incidence Risk and Sites Of Smnsmentioning

confidence: 99%

“…For hematological malignancies there is only evidence of risk if the primary Rb has been treated with alkylating chemotherapy, otherwise there are no or low risks for this SMN. Furthermore, no or low evidence of risks have been found for gastrointestinal malignancies (including colon cancer) and thyroid cancer [ 4 ]…”

Section: Incidence Risk and Sites Of Smnsmentioning

confidence: 99%

“…A recommendation guideline for long-term surveillance in heritable Rb survivors has been published in 2020 [ 4 ]. The panel first assessed the risk evidence for different types of SMNs ( Figure 4 a), the strongest risk evidence was seen for the sarcoma and melanoma.…”

Section: Long-term Surveillance In Heritable Rb Patientsmentioning

confidence: 99%

“…In the United States cohort, melanoma was detected in a late stage, possibly due to decreased visual acuity in this population. Therefore, it is strongly recommended that the Rb heritable survivors are educated on skin protection measures and have an annual skin exam [ 4 ]. Moreover, an annual visit to a long term follow-up clinic is recommended in order to ensure further patient education on prompt evaluation of potential SMN signs [ 10 ], such as for example persistent sinusitis, pain and skeletal tenderness.…”

Section: Long-term Surveillance In Heritable Rb Patientsmentioning

confidence: 99%

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Subsequent Malignant Neoplasms in Retinoblastoma Survivors

Fabius

Wijsard

Leeuwen

et al. 2021

Cancers

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Retinoblastoma (Rb) is a pediatric malignant eye tumor. Subsequent malignant neoplasms (SMNs) and trilateral Rb (TRb) are the leading cause of death in heritable Rb patients in developed countries. The high rate of SMNs in heritable Rb patients is attributed to the presence of a mutation in the RB1 tumor suppressor gene. In addition, Rb therapy choices also influence SMN incidence in this patient group. The incidence rates and age of occurrence for the most frequent SMNs and TRb will be discussed. In addition, the impact of genetic predisposition and Rb treatments on the development of SMNs will be evaluated. Furthermore, screening and other prevention methods will be reviewed.

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Section: Smn Definition and Reason Of Susceptibility In Heritable mentioning

confidence: 99%

Section: Incidence Risk and Sites Of Smnsmentioning

confidence: 99%

Section: Incidence Risk and Sites Of Smnsmentioning

confidence: 99%

Section: Long-term Surveillance In Heritable Rb Patientsmentioning

confidence: 99%

Section: Long-term Surveillance In Heritable Rb Patientsmentioning

confidence: 99%

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