1979
DOI: 10.1016/0165-1218(79)90015-6
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Recombinogenicity and mutagenicity of saccharin in Saccharomyces cerevisiae

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Cited by 23 publications
(5 citation statements)
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“…S. cerevisiae strain CM1069-40 (37) was inoculated at 5 ϫ 10 3 or 5 ϫ 10 5 cells per ml into nonsynthetic complete growth medium (YPAD [31]). …”
Section: Fungal Strains and Culturing Conditions A Fumigatus (Isolamentioning
confidence: 99%
“…S. cerevisiae strain CM1069-40 (37) was inoculated at 5 ϫ 10 3 or 5 ϫ 10 5 cells per ml into nonsynthetic complete growth medium (YPAD [31]). …”
Section: Fungal Strains and Culturing Conditions A Fumigatus (Isolamentioning
confidence: 99%
“…In the presence of S. cerevisiae saccharin was found to inhibit the sporulation process and slightly increase the occurrence of diploid and disomic meiotic products without affecting the frequency of recombination (Persic, 1986). At a concentrations of 2-20 mg/mL, sodium saccharinate did not significantly affect cell growth, but slightly reduced cells survival; cell survival decreased even more at a concentration of 100 mg/mL (Moore et al, 1979).…”
Section: Literature Studies On the Bioactivity Of Saccharin And Its D...mentioning
confidence: 81%
“…With FANFT, however, administration of an initiating dose requires 4 to 6 weeks of the chemical in the diet at a level of 0.2% (18). In vitro assays involving Saccharomyces have indicated that sodium saccharin is able to cause these genetic changes (47). The urinary bladder normally has a very low rate of cell turnover; the labeling index is approximately 4 per 10,000 epithelial cells (35).…”
Section: Cell Proliferation and Bladder Carcinogenesismentioning
confidence: 99%