2009
DOI: 10.1007/978-3-540-92165-3_13
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Recombinant Vectors as Influenza Vaccines

Abstract: The antiquated system used to manufacture the currently licensed inactivated influenza virus vaccines would not be adequate during an influenza virus pandemic. There is currently a search for vaccines that can be developed faster and provide superior, long-lasting immunity to influenza virus as well as other highly pathogenic viruses and bacteria. Recombinant vectors provide a safe and effective method to elicit a strong immune response to a foreign protein or epitope. This review explores the advantages and l… Show more

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Cited by 14 publications
(13 citation statements)
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References 135 publications
(135 reference statements)
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“…There has been interest in replicating viral vectors as candidates for HIV 2 or filovirus 3 vaccines, and adenoviruses have been noted as having particular benefits as potential recombinant-vector vaccines for influenza 4 and HIV 5 . Only a few replicating vector viruses, other than flavivirus chimeric recombinants between related flaviviruses, have advanced to phase 1 studies 6–10 .…”
Section: Introductionmentioning
confidence: 99%
“…There has been interest in replicating viral vectors as candidates for HIV 2 or filovirus 3 vaccines, and adenoviruses have been noted as having particular benefits as potential recombinant-vector vaccines for influenza 4 and HIV 5 . Only a few replicating vector viruses, other than flavivirus chimeric recombinants between related flaviviruses, have advanced to phase 1 studies 6–10 .…”
Section: Introductionmentioning
confidence: 99%
“…A number of vector systems have been employed to express influenza HA and other influenza virus proteins in recombinant vaccine candidates for human seasonal as well as potentially pandemic avian influenza viruses. 61 Some recombinant systems could allow faster and safer development of master seed viruses and vaccine production in large volumes at lower cost and with greater speed than conventional TIV. On the other hand, the vectored approach faces the challenge of anti-vector immunity, which can dampen the response to repeat immunization.…”
Section: Live Attenuated Influenza Vaccinesmentioning
confidence: 99%
“…Adenoviruses (Ads) are nonenveloped DNA viruses originally identified as infectious agents responsible for certain acute respiratory infections. Ad infection usually manifests as mild disease, which is promptly resolved; however, infection of immunocompromised individuals can result in more severe disease (88,89). Several properties of Ad viruses are attractive for vaccine use, including relative ease of manipulation, infection of both dividing and nondividing cells, high levels of transgene expression, ability to grow to high titers in vitro and lack of integration in the host genome and stability (physical and genetic) (87,89,90).…”
Section: Adenovirusesmentioning
confidence: 99%