Recombinant tumor necrosis factor causes activation of human granulocytes

Larrick, James W.; Graham, Delores E.; Toy, Karen; Lin, Leo S.; Senyk, George; Fendly, Brian M.

doi:10.1182/blood.v69.2.640.640

Cited by 155 publications

(29 citation statements)

References 22 publications

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“…When patients admitted because of sepsis or septic shock present elevated serum TNF-a levels (> 50 pg mL -1 ) at presentation, they have a better survival rate than those with low TNF-a levels [16]. It has been demonstrated that TNF-a is beneficial to the host because it will augment neutrophil functions, and these activated neutrophils will clear invading organisms more effectively [17]. In contrast, other studies did not correlate the presence of circulating TNF-a with the patients' outcome [18][19][20][21][22].…”

Section: Cytokines and Acute-phase Proteins In Pneumonia 313mentioning

confidence: 99%

Daily variation in circulating cytokines and acute‐phase proteins correlates with clinical and laboratory indices in community‐acquired pneumonia

Kosmas

Baxevanis

Papamichail

et al. 1997

Eur J Clin Investigation

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Our objective was to investigate the initial levels of circulating proinflammatory cytokines, such as interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), and tumour necrosis factor alpha (TNF-alpha), of certain acute-phase proteins, such as C-reactive protein (CRP), fibrinogen (FBN) and albumin, and of the glycoprotein fibronectin at presentation and their daily variation during the clinical course of community-acquired pneumonia (CAP) in relation to clinical and laboratory indices of infection. Thirty otherwise healthy hospitalized patients aged 48 +/- 3 years (mean +/- SEM) and with bacteriologically confirmed CAP were studied prospectively. IL-1 beta and IL-6 were found to be 15-fold higher on admission (122 +/- 9 pg mL-1 and 60 +/- 4 pg mL-1 respectively), whereas TNF-alpha was three-fold higher (102 +/- 5 pg mL-1) than those of controls, all of them showing a decline towards normal. Initial CRP levels were increased 90-fold (416 +/- 1 mg L-1), whereas fibronectin levels were reduced (242 +/- 9 mg dL-1). The presence of parapneumonic effusion was associated with a higher TNF-alpha serum level (127 +/- 7 vs. 86 +/- 4 pg mL-1, P = 0.0002), a more rapid daily decline in TNF-alpha (-7.2 +/- 0.7 vs. -3.8 +/- 0.5 pg mL-1 day-1, P = 0.0005), a slower rate of decline in CRP (-42.8 +/- 3.0 vs. -54.6 +/- 3.0 mg L-1 day-1, P = 0.02) and a slower rate of increase in FBN (5.9 +/- 1.0 vs. 11.7 +/- 1.0 mg dL-1 day-1), P = 0.001]. Furthermore, daily progression of serum levels of cytokines and acute-phase proteins correlated strongly with pyrexia, erythrocyte sedimentation rate (ESR), neutrophil count, alveolar-arterial oxygen difference and radiographic resolution, clinically manifested by improvement in the patients' condition.

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Section: Cytokines and Acute-phase Proteins In Pneumonia 313mentioning

confidence: 99%

Daily variation in circulating cytokines and acute‐phase proteins correlates with clinical and laboratory indices in community‐acquired pneumonia

Kosmas

Baxevanis

Papamichail

et al. 1997

Eur J Clin Investigation

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“…MD). To cxelude the influence of endotoxin, polymyxin B (Sigma) al a concentration of 5 /ig/ml was added to the cultures at the beginning of the culture period [12]. The supernatants were collected and the concentrations of lL-6.…”

Section: Measurement Of Cytokines By Elisamentioning

confidence: 99%

Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells

Yamashita

Nakajima

Takahashi

et al. 1993

Clinical and Experimental Immunology

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SUMMARYActivin A not oniy stimulates the synthesis and release of pituitary follicie-stimuiating honnone. but exerts various effects on haematopoietic cetis. embryos, and fibroblasts. In the present study we have examined effects of activin A on lgH synthesis and cytokine production by peripheral blood mononuciear ceiis (PBMt") in normai humans. When PBMC were cultuted in the prcsenee of lL-4. activin A significantiy augmented IgE production induced by IL-4. Activin A did not atlect, however, IgE production from highiy purified B ceiis when they were stimuiated with anti-CD4() MoAb and IL-4. The fact that in the iatter condition IgE synthesis was T ceii-and monocytc-indcpcndent indicated that activin A does not directiy inlluence B ceiis for IgE synthesis. Rather, production as weii as gene expression of IL-6, which is known to enhance IgE syntiiesis by puriiied monoeytes. was induced by activin A aione. In addition, activin A induced other monokines such as lL-l and tutnour necrosis factor (TNF)-a from monoeytes. In contrast, activin A neither induced nor augmented the production of TNF-/i or interferon-gamma (IFN-y). both of which arc known to be cxciusiveiy generated by Tceils. These data indicate that activin A piays a certain role in piiysioiogicat functions for monocyles in normal humans.

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“…Infusion of endotoxin elicits lymphopenia and a transient granulocytopenia followed by granulocytosis. While several investigators have tried to clarify the disappearance of granulocytes from peripheral blood during the granuloeytopenia [4,5] little is known about the fate ofthe lymphocytes during the lymphopenia: are the lymphocytes redistributed to other tissues, accumulating in the lungs or destroyed in the reticuloendothelial system ofthe liver?…”

Section: Introductionmentioning

confidence: 99%

Redistribution of Lymphocytes Following E. coli Sepsis

et al. 1993

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Infusion of endotoxin elicits lymphopenia and a transient granulocytopenia followed by granulocytosis in peripheral blood. The purpose of this study was to investigate which tissues the lymphocytes are redistributed to in response to endotoxaemia. Lymphocytes were isolated from the peripheral blood of 20 rabbits, labelled with 111Indium-tropolene and reinjected intravenously into the rabbits. Ten rabbits received an infusion of Escherichia coli endotoxin 2 micrograms/kg-1, while 10 rabbits received isotonic saline and served as a control group. The redistribution of lymphocytes was imaged with a gamma camera, and calculated with an interfaced computer before, and 2, 4 and 6 h after infusion of endotoxin or saline. Interleukin-1 beta and serum cortisol were measured. Following endotoxaemia the lymphocytes in peripheral blood decreased from 1.95 10(9)/l to 0.83 6 h later. Interleukin-1 beta and serum cortisol increased significantly. The radioactivity of labelled cells in the spleen and in the heart and lungs decreased to 83.3% and 87.8% of initial values respectively, 6 h after infusion of endotoxin. The radioactivity of the lymphatic tissue in and around the intestine increased to 128.8% of initial values. The results indicate that endotoxaemia induces redistribution of lymphocytes from peripheral blood and spleen to lymphatic tissue.

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Recombinant tumor necrosis factor causes activation of human granulocytes

Cited by 155 publications

References 22 publications

Daily variation in circulating cytokines and acute‐phase proteins correlates with clinical and laboratory indices in community‐acquired pneumonia

Daily variation in circulating cytokines and acute‐phase proteins correlates with clinical and laboratory indices in community‐acquired pneumonia

Effects of activin A on IgE synthesis and cytokine production by human peripheral mononuclear cells

Redistribution of Lymphocytes Following E. coli Sepsis

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