Recombinant Tissue Plasminogen Activator Administration in Patients With Cerebrovascular Accident; A Case Series

Abstract

Background: Cerebrovascular accident (CVA), as a debilitating neurological impairment, is one of the most common causes of death in adults. It is observed that CVA is less well-documented in the developing countries compared to the developed ones and most of the available data are based on case series. Objectives: The current study aimed to evaluate the effectiveness, feasibility, outcome, and safety of intravenous recombinant tissue plasminogen activator (IV rt-PA) administration in patients with acute ischemic cerebrovascular accident (CVA). Patients and Methods: All CVA patients referred three hours after onset of symptoms to the emergency department (ED) of Shohadaye Tajrish Hospital, Tehran, Iran, from February 2012 to March 2014 were included. The following data were collected using specific check list: demographic data, chief complaint, signs and symptoms, medical history, risk factors, focused neurologic examination, and the National Institutes of Health CVA Scale (NIHSS). Then, all patients received 0.9 mg/kg of rt-PA as a bolus intravenous dose and intravenous infusion under close monitoring in the ED. Outcomes were categorized as good (complete reversal of focal neurologic deficit), not bad (partial reversal of focal neurologic deficit), death, and unknown (missed follow up). Data were analyzed by STATA software version 11. Results: Fifteen patients with the mean age of 56.7 ± 18.9 years included in the study (male 66.7%). The most common chief complaints were left side hemiplegia (46.67%), right side hemiplegia (40%), and decreased level of consciousness (13.33%), respectively. The most common affected vascular territory was medial cerebral artery (MCA) (86.67%). There was no significant relationship between age (P = 0.06), gender (P = 0.08), NIHSS score (P = 0.07), location of infarct (P > 0.99) and mean time from admission to beginning the drug administration (P = 0.55) with the outcomes. The outcome in 26.7% of the patients was favorable and death (two of four) happened due to intra cranial hemorrhage (ICH) as rt-PA side effects. Conclusions: It seems that intravenous rt-PA administered three hours after CVA is bemeficial in patients with CVA and by reducing the early evaluation time and brain imaging can overcome the CVA complications. However, any conclusion from this study is limited by the small population under study.

Accuracy of Stroke Diagnosis Using FAST (Face, Arm, Speech, Time) Tool by Emergency Medical Service Dispatchers and Technicians and its Impact on Transport Time

“…In these cases, the blocked vessel can be opened by thrombolytic therapy or thrombectomy within a few hours of the onset of symptoms (2,3). However, a few patients receive such treatments, which is mainly due to the delay in arriving at a hospital (4,5). Emergency medical service (EMS) can play a vital role in this regard.…”

Epidemiological Features of Ischemic Brain Stroke; a Cross-Sectional Hospital-Based Study

“…The annual incidence of stroke has been estimated to be about 15 million cases that onethird die and one-third suffer from a permanent disability. In total, more than 80% of all stroke-induced deaths in the world occur in developing countries (1)(2)(3)(4)(5)(6)(7)(8). Previous studies have shown that the risk of stroke is doubled after the age of 55.…”

A clinical study investigation the three months prognosis of patients with ischemic stroke treated with recombinant tissue plasminogen activator (rtPA) and its effective factors

“…Many studies have been conducted on the efficiency of recombinant tissue plasminogen activator (rt-PA) and findings have revealed acceptable outcomes concerning the prescription of this drug between 3 and 4.5 hours after the onset of the symptoms (9). However, the use of this drug requires the proper awareness of the society in identifying stroke symptoms, early referral of patients, the quality of life, speed of laboratory and imaging services, timely visits by neurologist, early treatment and observing certain clinical principles (10,11). Due to several preventive factors in the prescription of the drug, only a small percentage of patients could receive the rt-PA (12).…”