Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells
Shao-Lei Geng,
Xiao-Jie Zhao,
Xi Zhang
et al.
Abstract:Mammalian cell lines are frequently used as the preferred host cells for producing recombinant therapeutic proteins (RTPs) having post-translational modified modification similar to those observed in proteins produced by human cells. Nowadays, most RTPs approved for marketing are produced in Chinese hamster ovary (CHO) cells. Recombinant therapeutic antibodies are among the most important and promising RTPs for biomedical applications. One of the issues that occurs during development of RTPs is their degradati… Show more
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