Recombinant RSV G protein vaccine induces enhanced respiratory disease via IL-13 and mucin overproduction
Eigo Kawahara,
Kota Senpuku,
Yoshino Kawaguchi
et al.
Abstract:The G protein expressed on the surface of respiratory syncytial virus (RSV) is important for adhesion to host cells and as a vaccine target antigen. The corresponding vaccines can effectively eliminate RSV. However, they exacerbate pulmonary immunopathology including eosinophilic infiltration in the lungs after an RSV challenge in animal models, raising concerns about enhanced respiratory disease (ERD); thus, approaches that mitigate these effects are urgently needed. Herein, we aimed to examine the mechanisms… Show more
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