Recombinant porcine NK-lysin inhibits the invasion of hepatocellular carcinoma cells in vitro

Khan, Abad; Fan, Kuohai; Sun, Na; Sun, Yaogui; Sun, Panpan; Jahejo, Ali Raza; Li, Hongquan

doi:10.1016/j.ijbiomac.2019.08.212

Cited by 5 publications

(10 citation statements)

References 47 publications

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“…Due to its expression pattern in HCC and the traits that it provides to the malignant cells, fascin-1 can serve as a promising therapeutic target to suppress advanced HCC and metastasis. Thus far, recombinant porcine natural killer lysin (rpNK-lysin) and doxycycline have been tested in this capacity ( Table 2 ) [ 99 , 100 ]. NK-lysin is a cationic anti-microbial peptide secreted by the interleukin-2 stimulated natural killer cells and cytotoxic T lymphocytes that halters HCC cell line proliferation and reduces their invasiveness and migration [ 99 ].…”

Section: Fascin-1 and Hepatocellular Carcinomamentioning

confidence: 99%

“…Thus far, recombinant porcine natural killer lysin (rpNK-lysin) and doxycycline have been tested in this capacity ( Table 2 ) [ 99 , 100 ]. NK-lysin is a cationic anti-microbial peptide secreted by the interleukin-2 stimulated natural killer cells and cytotoxic T lymphocytes that halters HCC cell line proliferation and reduces their invasiveness and migration [ 99 ]. These effects were possible due to rpNK-lysin-elicited downregulation of fascin-1 in a dose- and time-dependent manner [ 99 ].…”

Section: Fascin-1 and Hepatocellular Carcinomamentioning

confidence: 99%

“…NK-lysin is a cationic anti-microbial peptide secreted by the interleukin-2 stimulated natural killer cells and cytotoxic T lymphocytes that halters HCC cell line proliferation and reduces their invasiveness and migration [ 99 ]. These effects were possible due to rpNK-lysin-elicited downregulation of fascin-1 in a dose- and time-dependent manner [ 99 ]. The rpNK-lysin treatment further led to the disruption of the actin polymerization, the collapse of the finger-like protrusions, and the inhibition of tumor invasion and metastasis [ 99 ].…”

Section: Fascin-1 and Hepatocellular Carcinomamentioning

confidence: 99%

“…These effects were possible due to rpNK-lysin-elicited downregulation of fascin-1 in a dose- and time-dependent manner [ 99 ]. The rpNK-lysin treatment further led to the disruption of the actin polymerization, the collapse of the finger-like protrusions, and the inhibition of tumor invasion and metastasis [ 99 ]. At the maximum non-toxic concentration, rpNK-lysin had a selective cytotoxic effect for the HCC cells, while affecting less than 20% of normal hepatocytes [ 99 ].…”

Section: Fascin-1 and Hepatocellular Carcinomamentioning

confidence: 99%

“…The rpNK-lysin treatment further led to the disruption of the actin polymerization, the collapse of the finger-like protrusions, and the inhibition of tumor invasion and metastasis [ 99 ]. At the maximum non-toxic concentration, rpNK-lysin had a selective cytotoxic effect for the HCC cells, while affecting less than 20% of normal hepatocytes [ 99 ]. Furthermore, doxycycline successfully inhibited fascin-1 expression, and suppressed HCC proliferation and metastasis, and improved the animal survival outcomes [ 100 ].…”

Section: Fascin-1 and Hepatocellular Carcinomamentioning

confidence: 99%

See 4 more Smart Citations

Emerging Role of Fascin-1 in the Pathogenesis, Diagnosis, and Treatment of the Gastrointestinal Cancers

Ristić

Kopel

Sherazi

et al. 2021

Cancers

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Gastrointestinal (GI) cancers, including esophageal, gastric, colorectal, liver, and pancreatic cancers, remain as one of the leading causes of death worldwide, with a large proportion accounting for fatalities related to metastatic disease. Invasion of primary cancer occurs by the actin cytoskeleton remodeling, including the formation of the filopodia, stereocilia, and other finger-like membrane protrusions. The crucial step of actin remodeling in the malignant cells is mediated by the fascin protein family, with fascin-1 being the most active. Fascin-1 is an actin-binding protein that cross-links filamentous actin into tightly packed parallel bundles, giving rise to finger-like cell protrusions, thus equipping the cell with the machinery necessary for adhesion, motility, and invasion. Thus, fascin-1 has been noted to be a key component for determining patient diagnosis and treatment plan. Indeed, the overexpression of fascin-1 in GI tract cancers has been associated with a poor clinical prognosis and metastatic progression. Moreover, fascin-1 has received attention as a potential therapeutic target for metastatic GI tract cancers. In this review, we provide an up-to-date literature review of the role of fascin-1 in the initiation of GI tract cancers, metastatic progression, and patients’ clinical outcomes.

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Section: Fascin-1 and Hepatocellular Carcinomamentioning

confidence: 99%