Recombinant peptide derived from the venom the Phoneutria nigriventer spider relieves nociception by nerve deafferentation

Antunes, Flavia Tasmin Techera; Angelo, Stephanie Gonçalves; Dallegrave, Eliane; Picada, Jaqueline Nascimento; Marroni, Norma Possa; Schemitt, Elizângela Gonçalves; Ferraz, Alice Gomes; Gomez, Marcus V.; Souza, Alessandra Hübner de

doi:10.1016/j.npep.2019.101980

Cited by 14 publications

(4 citation statements)

References 51 publications

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“…27 Candidate explanations for the origin of deafferentation pain have emanated from clinical characterization, psychophysical studies, neuroanatomy, and imaging studies in conditions associated with deafferentation pain. 28,89,90 Animal models of phantom limb pain, 91 avulsion, 92 spinal cord injury, 93,94 and syringomyelia 95 employing behavioral, anatomical, imaging, and electrophysiologic methods suggest additional mechanisms. However, the validity of these models to recapitulate features of human deafferentation pain is not clear.…”

Section: Pain In the Context Of Sensory Deafferentationmentioning

confidence: 99%

Pain in the Context of Sensory Deafferentation

Cohen,

Caterina,

Yang

et al. 2024

Anesthesiology

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Pain that accompanies deafferentation is one of the most mysterious and misunderstood medical conditions. Prevalence rates for the assorted conditions vary considerably but the most reliable estimates are greater than 50% for strokes involving the somatosensory system, brachial plexus avulsions, spinal cord injury, and limb amputation, with controversy surrounding the mechanistic contributions of deafferentation to ensuing neuropathic pain syndromes. Deafferentation pain has also been described for loss of other body parts (e.g., eyes and breasts) and may contribute to between 10% and upwards of 30% of neuropathic symptoms in peripheral neuropathies. There is no pathognomonic test or sign to identify deafferentation pain, and part of the controversy surrounding it stems from the prodigious challenges in differentiating cause and effect. For example, it is unknown whether cortical reorganization causes pain or is a byproduct of pathoanatomical changes accompanying injury, including pain. Similarly, ascertaining whether deafferentation contributes to neuropathic pain, or whether concomitant injury to nerve fibers transmitting pain and touch sensation leads to a deafferentation-like phenotype can be clinically difficult, although a detailed neurologic examination, functional imaging, and psychophysical tests may provide clues. Due in part to the concurrent morbidities, the physical, psychologic, and by extension socioeconomic costs of disorders associated with deafferentation are higher than for other chronic pain conditions. Treatment is symptom-based, with evidence supporting first-line antineuropathic medications such as gabapentinoids and antidepressants. Studies examining noninvasive neuromodulation and virtual reality have yielded mixed results.

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Section: Pain In the Context Of Sensory Deafferentationmentioning

confidence: 99%

Pain in the Context of Sensory Deafferentation

Cohen,

Caterina,

Yang

et al. 2024

Anesthesiology

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“…induced antinociceptive effect in a rat model of neuropathic pain caused by nerve deafferentation, without causing motor alteration or genotoxicity in rats. Also, this peptide decreases the CSF levels of glutamate and the lipid peroxidation in the spinal cord induced by this pain model [ 144 ]. CTK 01512-2 i.v.…”

Section: N-type Vgccs Blockers Derived From Animal Venomsmentioning

confidence: 99%

Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage

Trevisan

Oliveira

2022

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: Pain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmitting painful stimuli from the periphery until the dorsal horn of the spinal cord. Thus, blocking voltage-gated calcium channels (VGCCs) can effectively control pain refractory to treatments currently used in the clinic, such as cancer and neuropathic pain. VGCCs blockers isolated of cobra Naja naja kaouthia (α-cobratoxin), spider Agelenopsis aperta (ω-Agatoxin IVA), spider Phoneutria nigriventer (PhTx3.3, PhTx3.4, PhTx3.5, PhTx3.6), spider Hysterocrates gigas (SNX-482), cone snails Conus geographus (GVIA), Conus magnus (MVIIA or ziconotide), Conus catus (CVID, CVIE and CVIF), Conus striatus (SO-3), Conus fulmen (FVIA), Conus moncuri (MoVIA and MoVIB), Conus regularis (RsXXIVA), Conus eburneus (Eu1.6), Conus victoriae (Vc1.1.), Conus regius (RgIA), and spider Ornithoctonus huwena (huwentoxin-I and huwentoxin-XVI) venoms caused antinociceptive effects in different acute and chronic pain models. Currently, ziconotide is the only clinical used N-type VGCCs blocker peptide for chronic intractable pain. However, ziconotide causes different adverse effects. The intrathecal route of administration also impairs its use in a more significant number of patients. In this sense, peptides isolated from animal venoms or their synthetic forms that modulate or block VGCCs channels seem to be a relevant prototype for developing new analgesics efficacious and well tolerated by patients.

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“…It reduced mechanical hyperalgesia induced by CCl in the sciatic nerve [13]. In a deafferentation pain model, CTK 01512-2 attenuated mechanical allodynia, cold allodynia, and thermal hyperalgesia without affecting the locomotor and exploratory activity of the rats [127]. Orofacial pain is a painful condition that affects the soft and hard tissues of the head, face, and neck [128,129].…”

Section: Recombinant Ctk 01512-2 Shows Effects Similar To the Native Phαβ Toxinmentioning

confidence: 99%

Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways

Silva

Binda

Pereira

et al. 2021

J. Venom. Anim. Toxins incl. Trop. Dis

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Recombinant peptide derived from the venom the Phoneutria nigriventer spider relieves nociception by nerve deafferentation

Cited by 14 publications

References 51 publications

Pain in the Context of Sensory Deafferentation

Pain in the Context of Sensory Deafferentation

Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage

Analgesic effects of Phα1β toxin: a review of mechanisms of action involving pain pathways

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