Recombinant Newcastle Disease Virus-Vectored Vaccines Against Human and Animal Infectious Diseases

Duan, Zhiqiang; Xu, Houqiang; Ji, Xinqin; Zhao, Jianjian

doi:10.2217/fmb.15.59

Cited by 20 publications

(14 citation statements)

References 131 publications

(168 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Successful delivery of HIV antigens has also been achieved using recombinant NDV vehicle [125]. Several live and inactivated vaccine candidates have been unsuccessful in the fight against the HIV pandemic, which continuously ravages the human population in different countries [126].…”

Section: Engineered Ndv As a Vaccine Vector In Manmentioning

confidence: 99%

Exploring the Prospects of Engineered Newcastle Disease Virus in Modern Vaccinology

Bello

Yusoff

Ideris

et al. 2020

Viruses

View full text Add to dashboard Cite

Many traditional vaccines have proven to be incapable of controlling newly emerging infectious diseases. They have also achieved limited success in the fight against a variety of human cancers. Thus, innovative vaccine strategies are highly needed to overcome the global burden of these diseases. Advances in molecular biology and reverse genetics have completely restructured the concept of vaccinology, leading to the emergence of state-of-the-art technologies for vaccine design, development and delivery. Among these modern vaccine technologies are the recombinant viral vectored vaccines, which are known for their incredible specificity in antigen delivery as well as the induction of robust immune responses in the vaccinated hosts. Although a number of viruses have been used as vaccine vectors, genetically engineered Newcastle disease virus (NDV) possesses some useful attributes that make it a preferable candidate for vectoring vaccine antigens. Here, we review the molecular biology of NDV and discuss the reverse genetics approaches used to engineer the virus into an efficient vaccine vector. We then discuss the prospects of the engineered virus as an efficient vehicle of vaccines against cancer and several infectious diseases of man and animals.

show abstract

Section: Engineered Ndv As a Vaccine Vector In Manmentioning

confidence: 99%

Exploring the Prospects of Engineered Newcastle Disease Virus in Modern Vaccinology

Bello

Yusoff

Ideris

et al. 2020

Viruses

View full text Add to dashboard Cite

show abstract

“…NDV-vectored vaccines have been evaluated in several animal species (i.e., chicken, cattle, sheep, cat, mouse, pig, and dog) for veterinary use [ 35 ] ( Table 2 ). NDV is a natural vaccine vector for poultry pathogens.…”

Section: Ndv As a Vaccine Vector For Veterinary Usementioning

confidence: 99%

Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines

Kim

Samal

2016

Viruses

108

View full text Add to dashboard Cite

Viral vaccine vectors have shown to be effective in inducing a robust immune response against the vaccine antigen. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising vaccine vector against human and veterinary pathogens. Avirulent NDV strains LaSota and B1 have long track records of safety and efficacy. Therefore, use of these strains as vaccine vectors is highly safe in avian and non-avian species. NDV replicates efficiently in the respiratory track of the host and induces strong local and systemic immune responses against the foreign antigen. As a vaccine vector, NDV can accommodate foreign sequences with a good degree of stability and as a RNA virus, there is limited possibility for recombination with host cell DNA. Using NDV as a vaccine vector in humans offers several advantages over other viral vaccine vectors. NDV is safe in humans due to host range restriction and there is no pre-existing antibody to NDV in the human population. NDV is antigenically distinct from common human pathogens. NDV replicates to high titer in a cell line acceptable for human vaccine development. Therefore, NDV is an attractive vaccine vector for human pathogens for which vaccines are currently not available. NDV is also an attractive vaccine vector for animal pathogens.

show abstract

“…Newcastle disease virus (NDV), a member of the genus Avulavirus within the family Paramyxoviridae , has a negative-sense, single-stranded, nonsegmented RNA genome with three sizes (15,186, 15,192, and 15,198 nucleotides [nt]) and encodes at least six viral proteins (1, 2). On the basis of the genomic size and cleavage site motif of the F protein, NDVs can be divided into two distinct classes, I and II.…”

Section: Genome Announcementmentioning

confidence: 99%

Complete Genome Sequences of Two Subgenotype 1b Newcastle Disease Viruses Isolated from Sansui Sheldrake Ducks in Guizhou, China

Huang

Duan

et al. 2016

Genome Announc

Self Cite

View full text Add to dashboard Cite

show abstract

Recombinant Newcastle Disease Virus-Vectored Vaccines Against Human and Animal Infectious Diseases

Cited by 20 publications

References 131 publications

Exploring the Prospects of Engineered Newcastle Disease Virus in Modern Vaccinology

Exploring the Prospects of Engineered Newcastle Disease Virus in Modern Vaccinology

Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines

Complete Genome Sequences of Two Subgenotype 1b Newcastle Disease Viruses Isolated from Sansui Sheldrake Ducks in Guizhou, China

Contact Info

Product

Resources

About