Recombinant neorudin and its active metabolite hirudin: the fate in vivo of a novel anticoagulant drug
Qiang Li,
Yubin Liu,
Boyuan Ren
et al.
Abstract:Thrombosis, a prevalent condition, can provoke severe health issues like acute coronary syndrome (ACS), deep vein thrombosis (DVT), and pulmonary embolism (PE). The rising incidence of these diseases annually significantly impacts patient wellbeing and poses a substantial burden on healthcare systems. Recombinant neorudin is a developing anticoagulant drug for thrombotic diseases whose phase I clinical trials has been completed. The distribution pattern of it and its active metabolite, hirudin, in thrombi, blo… Show more
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