Recombinant interferon alfa-2b treatment of necrobiotic xanthogranuloma with paraproteinemia

A 7-Year History of Necrobiotic Xanthogranuloma following Asymptomatic Multiple Myeloma: A Case Report

“…Chlorambucil appears to be the most effective treatment for patients with extensive cutaneous lesions [15–17]. Other systemic agents have been employed with some improvement including systemic steroid [18, 19], chlorambucil plus systemic corticosteroids, [7] cyclophosphamide, [20] melphalan, [21, 22] melphalan plus systemic corticosteroids, [23–25] azathioprine plus systemic corticosteroids, [26] thalidomide [27], and interferon- α 2b [7, 28]. All treatments can produce remission of paraproteinemia as well as skin lesions but, unfortunately, cannot prevent the evolution to multiple myeloma.…”

Necrobiotic xanthogranuloma associated with myeloma

“…In our patient, systemic symptoms were discarded after echocardiography, hepatic MRI, and chest X‐ray. Treatment of NXG has included chemotherapy with chlorambucil, 2,5,7,9 melphalan, 1,16,17 azathioprine, 1,5,9 methotrexate, 1,5,9 cyclophosphamide 7,18 and nitrogen mustard 1,5 associated with corticoids or, as monotherapy, surgical removal, 6,19–21 radiotherapy, 6 local corticoid injection, 4,5 pulsed high‐dose oral dexamethasone, 22 plasmapheresis 18,23 or interferon α‐2b 17 …”

Interferon Alpha-2a Monotherapy for Necrobiotic Xanthogranuloma

“…In 1995, Venencie et al (6) reported favourable therapeutic results of combined administration of oral prednisone (30 mg/day) and subcutaneous interferon alpha-2b (3610 6 IU/day three times a week) in a patient with NX resistant to either melphalan alone or in combination with prednisone. No clear conclusions can be drawn from this study with regard to the possible therapeutic value of interferon alpha in NX.…”