Recombinant Human Thyrotropin Administration Enhances Thyroid Uptake of Radioactive Iodine in Hyperthyroid Cats

Hoek, Ingrid van; Daminet, Sylvie; Vandermeulen, Eva; Dobbeleir, André; Duchateau, L.; Peremans, Kathelijne

doi:10.1111/j.1939-1676.2008.0191.x

Cited by 12 publications

(14 citation statements)

References 35 publications

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“…I n humans with multinodular goiter and thyroid cancer, recombinant human thyroid stimulating hormone (rhTSH) increases radioactive iodine thyroid uptake, allowing 131 I dose reduction, lower radiation‐absorbed doses by extrathyroidal organs and tissues, and higher treatment efficacy 1−4 . rhTSH also increases radioactive iodine thyroid uptake in the rhesus monkey and in hyperthyroid cats 5,6 …”

Section: Introductionmentioning

confidence: 99%

“…1À4 rhTSH also increases radioactive iodine thyroid uptake in the rhesus monkey and in hyperthyroid cats. 5,6 The use of rhTSH in thyroid carcinoma patients raises important safety issues. In humans, rhTSH increases the volume of the thyroid gland in healthy subjects 7,8 and causes expansion of primary thyroid tumors and thyroid tumor metastases.…”

Section: Introductionmentioning

confidence: 99%

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Short-Term Effect of Recombinant Human Thyroid-Stimulating Hormone on Thyroid Volume and Echogenicity in Healthy Beagles

Campos

Saunders

Duchateau

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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In humans, administration of recombinant human thyroid stimulating hormone (rhTSH) allows radioactive iodine dose reduction and higher efficacy in the treatment of multinodular goiter and thyroid cancer. A similar effect might be expected in dogs with thyroid carcinoma. However, if rhTSH leads to an increase in thyroid volume, it must be used carefully in dogs with large thyroid tumors to avoid compression of key anatomical structures. The aim of this study was to determine the short-term effect of rhTSH on thyroid volume and echogenicity, measured by ultrasonography, in healthy Beagles. Seven beagles were divided randomly in two groups in a prospective placebo-controlled blinded cross-over study. On day 1, one group received 100 microg of rhTSH intravenously and the other group received placebo. After a wash-out period of 3 weeks, the groups were crossed over. Evaluation of thyroid echogenicity, homogeneity, shape, capsule delineation, and measurement of thyroid length, width, and height were performed by the same observer at baseline, and at 6, 24, and 48h after injection of rhTSH and placebo. There was no significant difference between the effect of rhTSH and placebo on thyroid volume (P = 0.397), echogenicity, homogeneity, or capsule delineation. Time had a significant effect on thyroid volume (P = 0.027). No adverse effects after rhTSH administration were noticed. The effect of rhTSH on thyroid volume in dogs with thyroid carcinoma needs to be assessed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short-Term Effect of Recombinant Human Thyroid-Stimulating Hormone on Thyroid Volume and Echogenicity in Healthy Beagles

Campos

Saunders

Duchateau

et al. 2010

Veterinary Radiology &Amp; Ultrasound

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“…On the other hand, the lack of effect of rhTSH in hyperthyroid patients may be caused by decreased thyroid functional reserve. This seems, however, less likely because in hyperthyroid cats and in humans with toxic nodular goiter (a condition characterized by nodular enlargement of the thyroid gland and hyperthyroidism), a significant increase in thyroid RAIU is observed after rhTSH administration [18], [37].…”

Section: Discussionmentioning

confidence: 99%

“…Hence, in this study 123 I was chosen as an imaging agent, despite its high cost. Recent pilot studies performed by our group have already investigated the use of rhTSH to optimize the uptake of radioiodine-123 ( 123 I) in healthy dogs and hyperthyroid cats [17], [18]. The goal of this study was to evaluate the effect of 100 μg rhTSH, administered IV 24 h before 123 I, on tumor RAIU in dogs with thyroid tumors.…”

Section: Introductionmentioning

confidence: 99%

Effect of Recombinant Human Thyrotropin on the Uptake of Radioactive Iodine (123I) in Dogs with Thyroid Tumors

et al. 2012

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In humans, recombinant human thyrotropin (rhTSH) enhances radioactive iodine uptake (RAIU) in patients with differentiated thyroid cancer. No studies have been performed in veterinary medicine to optimize radioiodine treatment of thyroid cancer. The aim of this study was to evaluate the effect of rhTSH on the uptake of radioiodine-123 (123I) in dogs with thyroid tumors. Nine dogs with thyroid neoplasia were included in this prospective cross-over study. The dogs were divided in 2 groups. In one group, 123I was administered for a baseline RAIU determination in week 1. In week 2 (after a washout period of 2 weeks), these dogs received rhTSH (100 μg IV) 24 h before 123I injection. In the other group the order of the protocol was reversed. For each scan, the dogs received 37 MBq (1 mCi) of 123I intravenously (IV) and planar scintigraphy was performed after 8 and 24 h for tumor RAIU calculation. Overall, rhTSH administration caused no statistically significant change on thyroid tumor RAIU at 8 h (p = 0.89) or at 24 h (p = 0.98). A significant positive correlation was found between the effect of rhTSH on tumor 8h-RAIU and rhTSH serum concentrations at 6 h (τ = 0.68; p = 0.03), at 12 h (τ = 0.68; p = 0.03) and at 24 h (τ = 0.78; p = 0.02) after rhTSH injection. This study suggests that IV administration of 100 μg rhTSH 24 h before 123I has an inconsistent effect on thyroid tumor RAIU. Further studies are necessary to determine the best protocol of rhTSH administration to optimize thyroid tumor RAIU.

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“…12 In a small pilot study of hyperthyroid cats, RAIU was increased by administration of 25 μg rh-TSH, but changes were heterogeneous and of questionable clinical utility. 13 The authors speculated that increased rh-TSH doses could have resulted in greater and more consistent increases in RAIU. 13 Indeed, an in vitro study has shown that responsiveness of feline thyroid cells to TSH is dose dependent, and hyperthyroid cells require higher TSH concentrations than do normal cells to stimulate cellular activity and thyroglobulin expression.…”

Section: Introductionmentioning

confidence: 99%

Radioactive iodine uptake in hyperthyroid cats after administration of recombinant human thyroid stimulating hormone

Oberstadt

Nelson

Claude

et al. 2018

Veterinary Internal Medicne

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BackgroundRadioactive iodine therapy is considered the treatment of choice for hyperthyroidism in cats, but the availability of this modality is limited by costs and hospitalization requirements. Administration of recombinant human thyroid stimulating hormone (rh‐TSH) to humans with thyroid neoplasia or nodular goiter can increase thyroidal iodine uptake, thereby allowing the use of lower radioactive iodine doses for treatment. Veterinary studies of this subject are limited, and results are conflicting.ObjectiveTo investigate the effects of rh‐TSH administration on thyroidal iodine uptake in hyperthyroid cats.AnimalsTen client‐owned hyperthyroid cats.MethodsIn this prospective clinical study, cats were administered saline (placebo), 50 μg rh‐TSH (low‐dose), and 100 μg rh‐TSH (high‐dose) in randomized crossover design with treatments separated by 7‐10 days. After each treatment, thyroid scintigraphy was performed by administering 300 μCi 123I and assessing radionuclide uptake 8 and 24 hours later. Serum thyroid hormone concentrations were measured at each visit.ResultsThyroidal percent iodine uptakes (mean ± SD at 8 and 24 hours) in cats treated with placebo (25.2 ± 13.4%, 30.0 ± 12.8%), low‐dose (24.1 ± 12.5%, 29.4 ± 13.7%), and high‐dose rh‐TSH (24.2 ± 16.3%, 30.8 ± 15.3%) were not different (P = .76). Independent of rh‐TSH administration, percent iodine uptakes were positively correlated with serum thyroid hormone concentrations.Conclusions and Clinical ImportanceOne‐time administration of rh‐TSH, even at high doses, would not be expected to lower radioactive iodine doses needed for treatment of hyperthyroidism in cats. Investigations of alternate strategies to increase thyroidal uptake of radioactive iodine are warranted.

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Recombinant Human Thyrotropin Administration Enhances Thyroid Uptake of Radioactive Iodine in Hyperthyroid Cats

Abstract: Background: Hyperthyroidism is the most diagnosed endocrine disorder in cats and radioiodine (

Cited by 12 publications

References 35 publications

Short-Term Effect of Recombinant Human Thyroid-Stimulating Hormone on Thyroid Volume and Echogenicity in Healthy Beagles

Short-Term Effect of Recombinant Human Thyroid-Stimulating Hormone on Thyroid Volume and Echogenicity in Healthy Beagles

Effect of Recombinant Human Thyrotropin on the Uptake of Radioactive Iodine (123I) in Dogs with Thyroid Tumors

Radioactive iodine uptake in hyperthyroid cats after administration of recombinant human thyroid stimulating hormone

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