Recombinant Human Platelet-Derived Growth Factor BB for Reconstruction of Human Large Extraction Site Defects

Tissue engineering for bone regeneration and osseointegration in the oral cavity

“…Due to the small sample size and weak defect standardization it was not possible to draw a clear line between groups; nevertheless, ridge morphology for implant placement was more convenient for the PDGF-BB group. More recently, the same group [138] studied in a case-series the effect of PDGF-BB in combination with equine/bovine grafting materials on bone regeneration of large extraction site defects. Histologic results revealed new bone formation in association with remaining graft particles and no evidence of inflammatory cell infiltration.…”

Lateral bone augmentation in narrow posterior mandibles, description of a novel approach, and analysis of results

“…A large body of evidence shows that survival rates of dental implants placed in conjunction with GBR are similar to those placed in native bone . GBR principles are creation and maintenance of a secluded space for the desired period, which is achieved by application of resorbable or nonresorbable membranes and bone‐grafting materials . The application of particulate bone grafts covered with resorbable collagen membrane is apparently the most widely used and best documented method for bone augmentation .…”

The use of bioactive factors to enhance bone regeneration: A narrative review

“…No significant differences in terms of newly formed bone were detected when rhPDGF‐BB was combined with β‐TCP or a bovine/equine particulate graft (McAllister et al., ; Nevins, Reynolds, Camelo, Schupbach & Kim, ). Moreover, in an RCT in 16 patients, no significant differences in newly bone formation were observed in sockets grafted with MCBS loaded with rhPDGF‐BB compared to sockets treated with MCBS only, MCBS and an enamel matrix derivative, or an enamel matrix derivative and a bone ceramic graft (Nevins, Camelo, Schupbach, Nevins & Kim, ).…”