2020
DOI: 10.1007/s10637-020-01020-2
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Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities

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Cited by 23 publications
(19 citation statements)
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“…Additionally, the extract was active against bacteria and yeast, and the obtained results suggest that antifungal mode of action is associated with disruption of cell membrane permeability. Previously, it was published that some natural products, like green barley extract [ 44 ], and lactoferrin [ 45 ] exhibited an antiproliferative activity on cancer cells, making our results in agreement with literature pointing to the anticancer effects of natural products. Altogether, the obtained results serve as a good basis for further research of the anti-glioblastoma and antimicrobial mechanisms of actions of herba Anthrisci cerefolii .…”
Section: Discussionsupporting
confidence: 92%
“…Additionally, the extract was active against bacteria and yeast, and the obtained results suggest that antifungal mode of action is associated with disruption of cell membrane permeability. Previously, it was published that some natural products, like green barley extract [ 44 ], and lactoferrin [ 45 ] exhibited an antiproliferative activity on cancer cells, making our results in agreement with literature pointing to the anticancer effects of natural products. Altogether, the obtained results serve as a good basis for further research of the anti-glioblastoma and antimicrobial mechanisms of actions of herba Anthrisci cerefolii .…”
Section: Discussionsupporting
confidence: 92%
“…In addition, glycosylation has complex significance on the function of proteins. For example, N-glycosylation can increase protein stability [ 35 ]. The N-glycosylation of Asn-297 of murine IgG can enhance immune response.…”
Section: Discussionmentioning
confidence: 99%
“…Although this bacteria-heteroexpressed HSPB5 exerts chaperone activity, it cannot completely imitate the HSPB5 secreted by mammalian cells due to a lack of posttranslational modification [ 33 , 34 ]. Earlier, it has been reported that human recombinant lactoferrin, carrying a humanized glycosylation, displays selective antiproliferative effects on cancer cells [ 35 ]. This research suggests that natural recombinant proteins possess beneficial biological activities on human health.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, it is known that many cancer cells have a high content of proteoglycan, glycosaminoglycan and sialic acid, which are known to interact with Lf, which probably activates other signaling pathways to generate harmful effects to cells [ 66 ]. This possible mechanism will also explain the high cytotoxic selectivity that Lf has on cancer cells and not on healthy cells [ 65 , 67 , 68 , 69 , 70 ]. Despite the fact that various authors showed that Lf has high selective cytotoxicity, not all reported the selective cytotoxicity index (SCI), which gives the ability of a compound to kill cancer cells with minimal toxicity to non-cancer cells.…”
Section: Anticancer Activitymentioning
confidence: 99%
“…Currently, treatments for different types of leukemia, including acute myeloid leukemia and acute lymphoid leukemia, improve the survival rate in diagnosed children; however, the long-term consequences can manifest as cardiovascular diseases that increase the risk of death [ 82 , 83 ]. In this sense, once again, Lf could be an alternative that minimizes side effects in patients, since it was shown to induce apoptosis in leukemia [ 70 , 84 ]. In the same way that Lf has been successfully tested for the treatment of cancers, primarily breast cancer, both Lf and bioactive Lf-derived peptides have been used successfully in the treatment of other types of cancer such as leukemia.…”
Section: Anticancer Activitymentioning
confidence: 99%