Recombinant human erythropoietin for the correction of cancer associated anemia with and without concomitant cytotoxic chemotherapy

Abstract

Background. Chronic anemia is a common complication in patients with cancer, especially in those with advanced disease or who are under intensive chemotherapy. Because homologous blood transfusions involve some hazards, the safety and efficacy of recombinant human erythropoietin (r‐HuEPO) in the treatment of anemic patients with cancer with and without concomitant chemotherapy were studied. Methods. One‐hundred two cancer patients with hemoglobin less than 11 g/dl, ferritin greater than 30 μg/l, and creatinine < 220 μmol/l were enrolled in the study, 94 were eligible for efficacy evaluation. Sixty‐eight patients received chemotherapy (CT group) and 26 had no cytotoxic cancer treatment (NT group). Recombinant human erythropoietin was administered subcutaneously at a dose of 150 U/kg three times per week for 6 weeks; in nonresponders the dose was doubled for the subsequent 6 weeks. Response was defined as the achievement of a hemoglobin increase of 2 g/dl. Clinical and laboratory parameters, including serum erythropoietin (EPO) levels, performance status, and quality of life, were investigated at baseline and monitored at regular intervals thereafter. Results. Response was achieved by 52% and 62% of CT and NT patients, respectively. The highest response rates were observed in patients with lung cancer or with a histology of squamous cell carcinoma (both 80%). In responding patients, the symptoms of anemia subsided. They no longer needed blood transfusions after 4 weeks of therapy; and both their performance status and quality of life improved significantly. The NT patients achieved slightly more favorable results on lower weekly doses: 450 U/kg/week in NT versus 570 U/kg/week in CT patients. Serum EPO levels were higher in nonresponders at baseline and further increased during the course of treatment. Recombinant human erythropoietin was well tolerated by all patients. Conclusion. This multicenter study in a large patient collective shows that r‐HuEPO treatment represents a safe and effective means to increase the red cell mass and eliminate the need for blood transfusions in approximately 50% of the patients with chronic anemia of cancer. Responding patients not only have increased levels of hemoglobin, but their performance status also improves significantly, and they enjoy a significantly enhanced quality of life. Cancer 1995; 76:2319–29.

Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy

“…Numerous studies, both placebo-controlled and open-label, have consistently shown that increasing haemoglobin values has a measurable and significant effect on QOL parameters in cancer patients whether they are receiving (Abels, 1993;Case et al, 1993;Henry and Abels, 1994;Leitgeb et al, 1994;Glaspy et al, 1997;Demetri et al, 1998) or not receiving concurrent chemotherapy (Ludwig et al, 1995). In all of these studies, haemoglobin was increased by the administration of recombinant human erythropoietin (rHuEPO, epoetin alfa).…”

Optimized pro-active management of anemia by Epoetin α in pre-operative chemotherapy for primary breast cancer

“…Moreover, many chemotherapy patients suffer from a chronic state of exhaustion, known as fatigue syndrome. This syndrome occurs frequently in combined radiation, endocrine, and chemotherapy regimens (25). It leads to reduced quality of life and may be associated with cognitive impairment.…”

A European perspective on haematopoietic growth factors in haemato-oncology: Report of an expert meeting of the EORTC

“…It is produced in response to tissue hypoxia, mainly (85-90%) by renal tubular interstitial cells [6] and to a minor degree also by liver and bone marrow (BM) macrophages [7], Red cell transfusion carries the risk of transmission of infections as well as transfusion reactions. Administration of EPO has convincingly been shown to increase haematocrit and decrease transfusion requirement in 40-70% of patients with chronic anaemia of cancer [8,9]. It also prevents or ameliorates anaemia in patients undergoing chemotherapy with or without cisplatin [8,10] and improves haemoglobin levels in HIV infected patients experiencing anaemia while receiving zidovudine treatment [11].…”