1990
DOI: 10.1016/0952-0600(90)90036-i
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Recombinant human C5a-induced bronchoconstriction in the guinea-pig: A histamine independent mechanism

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Cited by 10 publications
(9 citation statements)
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“…It is known that C5a induces the release of not only TNF-␣, but also a host of other inflammatory cytokines and various mediators that are reportedly also involved in IBD (22,23,53). Because the C5a antagonist used in our study is also known to prevent formation of a number of these mediators (21)(22)(23), this likely explains its greater efficacy over infliximab, which solely inhibits TNF-␣.…”
Section: Discussionmentioning
confidence: 76%
“…It is known that C5a induces the release of not only TNF-␣, but also a host of other inflammatory cytokines and various mediators that are reportedly also involved in IBD (22,23,53). Because the C5a antagonist used in our study is also known to prevent formation of a number of these mediators (21)(22)(23), this likely explains its greater efficacy over infliximab, which solely inhibits TNF-␣.…”
Section: Discussionmentioning
confidence: 76%
“…Although the exact functions that C3a and C5a regulate in human lung disease require further examination, C3a and C5a have been shown to elicit functional responses in the lung. In guinea pigs, instillation of C3a or C5a into the lungs induces respiratory distress characterized by contraction of the smooth muscle in bronchioles and pulmonary arteries and recruitment of platelets and leukocytes in pulmonary vessels (51,52).…”
Section: Discussionmentioning
confidence: 99%
“…Instillation of the anaphylatoxins induces respiratory distress characterized by contraction of the smooth muscle walls in bronchioles and pulmonary arteries and aggregation of platelets and leukocytes in pulmonary vessels (51,52). Synthetic peptides, based on the carboxyl-terminal sequence of C3a, can also mimic these properties (53), and the addition of inhibitors to carboxypeptidase N potentiates the respiratory distress stimulated by instillation of C3a and C5a (54,55).…”
mentioning
confidence: 99%
“…Bronchoconstriction was not altered by pyrilamine despite an increase in plasma histamine levels. SQ 29,548, a selective thromboxane antagonist decreased the peak response only, while the superoxide dismutase and TXA2 inhibitor U-63557A altered the time course of the bronchoconstrictor response (39). The time course and magnitude of bronchoconstriction was not affected by selective depletion of PMN, platelets or both.…”
Section: Effects Of Complement Components C3a and C5a In The Guinea Pigmentioning
confidence: 82%