2012
DOI: 10.1016/j.fertnstert.2011.12.011
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Recombinant H2 relaxin inhibits apoptosis and induces cell proliferation in cultured leiomyoma cells without affecting those in cultured normal myometrial cells

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Cited by 11 publications
(12 citation statements)
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“…tissue invasion, and tumour angiogenesis [3][4][5], and inhibiting apoptosis [6]. RLN2-mediated RXFP1 activation contributes to tissue invasion and metastasis of tumour cells in several ways.…”
Section: No Conflicts Of Interest Were Declaredmentioning
confidence: 99%
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“…tissue invasion, and tumour angiogenesis [3][4][5], and inhibiting apoptosis [6]. RLN2-mediated RXFP1 activation contributes to tissue invasion and metastasis of tumour cells in several ways.…”
Section: No Conflicts Of Interest Were Declaredmentioning
confidence: 99%
“…The heterodimeric peptide hormone relaxin binds to the G‐protein‐coupled receptor RXFP1 and is up‐regulated in cancer . The main human relaxin isoform, RLN2, can promote tumour progression in a tumour‐specific context by enhancing tumour cell proliferation, tissue invasion, and tumour angiogenesis , and inhibiting apoptosis . RLN2‐mediated RXFP1 activation contributes to tissue invasion and metastasis of tumour cells in several ways.…”
Section: Introductionmentioning
confidence: 99%
“…Mediator subcomplex 12 is a protein involved in the organisation of the transcription machinery showing a high degree of evolutionary conservation among mammalian species in particular in the region encoded by the UL-hotspot region [8]. While UL-derived cell cultures are a wide-spread model system for research into the pathogenesis and behavior of the tumors [2, 911] recent results challenge the usefulness of this model for the group of tumors carrying MED12 mutations. Contrary to the expectations a rapid loss of mutated cells accompanied in vitro growth of UL-derived cell cultures [12].…”
Section: Introductionmentioning
confidence: 99%
“…In human osteosarcoma cells, relaxin promotes faster in vitro growth, invasion, and angiogenesis via the Akt and VEGF pathways, and small interfering RNA-mediated knockdown of relaxin greatly mitigates these effects (Ma et al, 2013a,b). The peptide hastens the proliferation of human leiomyoma cells (Suzuki et al, 2012). A clinical study in 108 patients with hepatocellular carcinoma identified expression of relaxin in tumor tissue as an independent predictor of poor prognosis (Pan et al, 2013).…”
mentioning
confidence: 99%