Recombinant GH replacement in hypopituitary adults improves endothelial cell function and reduces calculated absolute and relative coronary risk

Abstract

Biophysical test of endothelial function (FMD) improved after 12 months of GH therapy but there was no significant change in biochemical endothelial or inflammatory markers. Calculated coronary risk decreased mainly due to reduction in systolic and diastolic blood pressure and increase in HDL-cholesterol.

Recombinant human GH replacement increases CD34+ cells and improves endothelial function in adults with GH deficiency

“…In addition, abnormalities in vascular function and structure have been described in GHD (3)(4)(5). Recombinant human GH (rhGH) replacement in GHD is aimed at reversing these abnormalities (6)(7)(8)(9)(10).…”

Association of serum IGF1 with endothelial function: results from the population-based study of health in Pomerania

“…Since the authors did not present data analysis separately for men (nZ65) and women (nZ35), it cannot be excluded that the observed association of IGF1 levels and acetylcholine-induced forearm blood flow in their whole population was due to the preponderance of male subjects. Other studies focussing on the relationship of serum IGF1 levels and endothelial function were even smaller and primarily confined to patients with disturbed GH secretion, such as acromegaly or GH deficiency (15)(16)(17). In patients with low (15,16) and high (17) preinterventional serum IGF1 levels, normalization of IGF1 levels led to an improvement of previously reduced FMD.…”

“…Other studies focussing on the relationship of serum IGF1 levels and endothelial function were even smaller and primarily confined to patients with disturbed GH secretion, such as acromegaly or GH deficiency (15)(16)(17). In patients with low (15,16) and high (17) preinterventional serum IGF1 levels, normalization of IGF1 levels led to an improvement of previously reduced FMD. In these studies, gender-specific analysis was either not discussed or considered impossible due to the small number of patients (15).…”

“…In patients with low (15,16) and high (17) preinterventional serum IGF1 levels, normalization of IGF1 levels led to an improvement of previously reduced FMD. In these studies, gender-specific analysis was either not discussed or considered impossible due to the small number of patients (15). Our study comprised 1482 subjects with a broad age range (25-85 years) and IGF1 levels largely within the reference range, which points toward a relevant impact of IGF1 on the cardiovascular system in male subjects under physiological circumstances.…”

“…In patients with low serum IGF1 levels due to GH deficiency, substitution of GH leads to normalization of a previously reduced FMD (15,16). On the other hand, in acromegaly patients with high IGF1 levels, surgical resection of the GH-producing tumor was followed by an improvement of previously reduced FMD (17).…”