Recombinant factor viia for refractive haemorrhage in autoimmune idiopathic thrombocytopenic purpura

How I treat idiopathic thrombocytopenic purpura (ITP)

“…38 Recombinant factor VIIa may be added in patients unresponsive to other modalities if an immediate response is necessary, such as with ICH. 39 IVIG is generally well tolerated other than for a postinfusion headache. Rarely, patients develop aseptic meningitis, acute renal failure, pulmonary insufficiency, thrombosis, or hemolysis; dissolving lyophilized preparations in sterile water to lower osmolarity and slowing the infusion rate may lessen these risks.…”

Postoperative pulmonary thromboembolism possibly associated with recombinant activated factor VII infusion for the treatment of uncontrolled hemorrhage during vertebral instrumentation

“…Successful use of rFVIIa in controlling bleeding in patients with thrombocytopenia has been reported [8,9,13,14]. High concentrations of rFVIIa activate platelets, and generate platelet surface factors IXa and Xa, ultimately leading to thrombin generation [15].…”

Unlabeled uses of factor VIIa (recombinant) in pediatric patients

“…25 No patient had complete cessation of bleeding after the first dose, but all had reduced blood product requirements. Eleven case reports and case series involving 33 patients with coagulopathies have been published, [27][28][29][30][31][32][33][34][35][36][37] with the most common coagulopathy being Glanzmann thrombasthenia, a rare congenital disorder of platelet function. Almeida et al 33 studied 7 patients age 2.5-11 years with inherited platelet disorders, 5 of whom were diagnosed with Glanzmann thrombasthenia.…”