Recollections and Reflections on Education, Diabetes, Other Metabolic Diseases, and Nutrition in the Mayo Clinic and Associated Hospitals, 1919-50

Wilder, Russell M.

doi:10.1353/pbm.1958.0019

Cited by 3 publications

(6 citation statements)

References 15 publications

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“…Ketogenic diets espouse low carbohydrate consumption. This limits the availability of glucose as an energy source, thus necessitating the use of ketones for generation of acetyl-CoA and ATP [120]. This utilization of ketones, which are a less efficient substrate for glycolysis, promotes mitochondrial adaptation via increased transcription of mitochondrial genes, thereby enhancing mitochondrial biogenesis and bioenergetic efficiency [121].…”

Section: Purinergic Signalingmentioning

confidence: 99%

Purinergic Signaling and Energy Homeostasis in Psychiatric Disorders

Lindberg¹,

Shan²,

Ayers-Ringler³

et al. 2015

CMM

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Purinergic signaling regulates numerous vital biological processes in the central nervous system (CNS). The two principle purines, ATP and adenosine act as excitatory and inhibitory neurotransmitters, respectively. Compared to other classical neurotransmitters, the role of purinergic signaling in psychiatric disorders is not well understood or appreciated. Because ATP exerts its main effect on energy homeostasis, neuronal function of ATP has been underestimated. Similarly, adenosine is primarily appreciated as a precursor of nucleotide synthesis during active cell growth and division. However, recent findings suggest that purinergic signaling may explain how neuronal activity is associated neuronal energy charge and energy homeostasis, especially in mental disorders. In this review, we provide an overview of the synaptic function of mitochondria and purines in neuromodulation, synaptic plasticity, and neuron-glia interactions. We summarize how mitochondrial and purinergic dysfunction contribute to mental illnesses such as schizophrenia, bipolar disorder, autism spectrum disorder (ASD), depression, and addiction. Finally, we discuss future implications regarding the pharmacological targeting of mitochondrial and purinergic function for the treatment of psychiatric disorders.

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Section: Purinergic Signalingmentioning

confidence: 99%

Purinergic Signaling and Energy Homeostasis in Psychiatric Disorders

Lindberg¹,

Shan²,

Ayers-Ringler³

et al. 2015

CMM

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“…Following her training at the University of Chicago in chemistry, Carol Beeler was hired by Dr Henry Helmholz and Dr Samuel Amberg at the Otho S.A. Sprague Memorial Institute in Chicago. 24 With Helmholz, Beeler published ''Experimental Pyelitis in the Rabbit'' in JU in 1918, becoming the second woman author. 2 In 1920, Beeler moved to Minnesota where she began work at the Mayo Clinic with Dr Russell Wilder, a pioneering endocrinologist.…”

Section: Carol Beelermentioning

confidence: 99%

The first female authors of the Journal of Urology

et al. 2017

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Introduction In 1917, Alma Hiller became the first woman to publish in the Journal of Urology ( JU). Her contribution was followed by articles from Carol Beeler and Isabel Mary Wason. This study explores their careers and contributions. Methods We reviewed JU articles from 1917 to 1925 and identified Hiller, Beeler, and Wason as the first three women authors. Using public records, we obtained information of their educations and careers. Results Hiller demonstrated resilience in obtaining training and ultimately contributed to innovation in clinical chemistry. Beeler worked on research on metabolic physiology. Wason influenced both lab work and national policy. Conclusions For female scientists entering the workforce in the late 1800s/early 1900s, reception was contingent upon the acceptance of male colleagues. Despite these barriers, Hiller, Beeler, and Wason contributed to novel discoveries. Their most influential contributions remain their historic presence as early female researchers and the first female authors in JU.

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“…Dr Russell Wilder believed that Rowntree's arrival at the clinic was the reason for William Osler's statement, made in 1919, that the Mayo's were wise men to make the clinic as important in medicine as it was in surgery. 9 Rowntree's group formed a new section within the clinic, bringing the total number of medical sections to 8. Dr Henry Plummer, who retained the title of Chief of Medicine of the Mayo Clinic, headed the other 7 sections.…”

Section: Johns Hopkinsmentioning

confidence: 99%

“…Waltman Walters, 17 whose research career also was aided by Rowntree, recalled, "The greatest stimulus to research…in my opinion, was that brought to the Clinic by Leonard Rowntree." Russell Wilder 9 explained, "At the Mayo Clinic the clinical investigations of the twenties, the thirties and the forties, in arthritis, gastroenterology, diseases of the liver, nephritis, hypertension, diseases of the arteries and veins, diabetes, hyperinsulinism, hyperparathyroidism, Addison's disease and nutrition, must almost all be credited to the clinical investigators of the Rowntree group.…" WHY ROWNTREE LEFT THE MAYO CLINIC Unlike his colleagues, Rowntree never became assimilated into the Mayo Clinic's structure and routine. Over the years, he spent less and less time caring for patients and instead devoted his energies to clinical investigation and the supervision of projects carried out by his fellows.…”

Section: Johns Hopkinsmentioning

confidence: 99%

“…Plummer had "expressed concern, lest Rowntree's department, growing at St. Mary's Hospital, which he called a clinic within the Clinic, become a rival of the Clinic." 9 Another element contributing to the Rowntree family leaving Rochester may have been increasingly strained relations between his family and W. J. Mayo. 20 Rowntree, writing a quarter of a century later, explained that when he left the Mayo Clinic in 1932, W. J. Mayo was somewhat upset with him 1 : "I explained to him that I had no criticism of the Clinic, but sought other opportunities in life and a different environment, but he was not completely mollified."…”

Section: Johns Hopkinsmentioning

confidence: 99%

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